<![CDATA[Staphylococcus aureus is an opportunistic pathogen that causes skin and systemic infections, which can lead to serious complications. Resistance to conventional antibiotics poses a major challenge in treating these infections. This study aims to determine the antibacterial activity of a transdermal patch containing methanol extract of Moringa oleifera Lam. bark against Staphylococcus aureus. The study design is experimental, using a transdermal patch formulation containing the extract in three different concentrations (4%, 8%, and 12%). The evaluation was conducted on the physical properties of the patch, including organoleptic properties, pH, weight uniformity, thickness, fold resistance, and stability test. The preference test and antibacterial activity test were conducted using the well diffusion method. The results showed that all patch formulations met the requirements for good physical characteristics. Antibacterial activity increased with increasing extract concentration, with the highest inhibition zone (21.06 mm) observed at 12% extract concentration. The acceptability test showed that the patch formulation was well accepted by the respondents. Thus, the transdermal patch formulation of methanolic extract of moringa bark has the potential as an alternative treatment for skin infections caused by Staphylococcus aureus.]]>
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