This study examined the challenges and opportunities of integrating Artificial Intelligence in teaching and learning in secondary schools in Gusau Educational Zone, Zamfara State. The study was guided by three research objectives and three hypotheses. A descriptive survey research design was adopted, and a sample of 384 respondents was selected using stratified and simple random sampling techniques. Data were collected using a structured questionnaire with a reliability coefficient of 0.89, indicating high internal consistency. Pearson Product Moment Correlation and independent samples t-test were used to analyze the data at a 0.05 level of significance. The findings revealed a significant positive relationship between Artificial Intelligence integration and teaching and learning opportunities, indicating that AI enhances instructional delivery and learner engagement. It was also found that there is a significant negative relationship between challenges and effective AI integration, showing that existing barriers reduce the effectiveness of AI in education. Furthermore, a significant difference was observed in the level of AI utilization between teachers and students, with teachers demonstrating higher usage. The study concludes that while Artificial Intelligence has strong potential to improve teaching and learning outcomes, its effectiveness is influenced by infrastructural, technical, and capacity-related challenges. The study recommends improved infrastructure, training, and equitable access to digital tools
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