<![CDATA[Background: The hormonal contraceptive DMPA (Depot Medroxyprogesterone Acetate) is an injectable contraceptive method widely used by women of childbearing age because it is practical and effective in preventing pregnancy. However, prolonged use of DMPA can cause side effects, one of which is secondary amenorrhea. Secondary amenorrhea is the absence of menstruation for three consecutive months or more in women who previously had normal menstruation. The occurrence of secondary amenorrhea often causes anxiety in DMPA users, so research is needed regarding the relationship between DMPA use and the occurrence of secondary amenorrhea. Method: This study employed an analytical design with a cross-sectional approach. A sample of 30 respondents was selected using purposive sampling. The research instruments used were observation sheets and questionnaires. Data analysis used the Chi-Square test with the help of SPSS. Results: The majority of respondents (18 respondents (60.0%) used DMPA hormonal contraception for more than 1 year. Nineteen respondents (63.3%) experienced secondary amenorrhea. The Chi-Square test results showed a p-value of 0.002 (<0.05), indicating a significant relationship between DMPA hormonal contraception use and the incidence of secondary amenorrhea in the Popayato Barat Community Health Center UPTD area. Conclusion: There is a significant relationship between the use of DMPA hormonal contraception and the incidence of secondary amenorrhea in the Popayato Barat Community Health Center UPTD area.]]>
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