This study aims to develop STEM-based learning with the help of ICT to improve 21st century skills. This research is a Pre-experiment research with research design used "one group Pretest-posttest design". The sample consisted of 6 classes and 32 students were selected as one class. On the improvement of students' critical thinking skills, the average score of the pretest was 69.03 and the average score of the posttest was 82.44 with an N-gain of 0.45 in the medium category. While the improvement of students' creative thinking skills obtained an average pretest score of 74.63 and an average posttest score of 87.97 with an N-Gain of 0.56 in the medium category. While the improvement of communication and collaboration skills obtained a percentage above 66%, communication skills gained 67.13% results and collaboration skills obtained by 74.75% and included in both categories. Student responses obtained results of more than 61%, amounting to 68.06%, including the good category as well. For the effectiveness of the learning outcomes obtained results above 61% which is 72.63%. So it can be concluded that Science, Technology, Engineering and Mathematic (STEM) Science-Based Learning (ICT) assisted with ICT can improve 21st Century skills and run well.
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