The development of inquiry-based IPA practicum guide book can be used to reference the implementation of IPA practicum at At-Thayyibah Semurup Junior High School. The purpose of this study is to obtain the results of the validity and practicality of guided IPA learning guide books. This research is a type of development research using the ADDIE model (analysis, design, development, implementation, and evaluation). This research was conducted at At-Thayyibah Semurup Middle School. The product developed in grades by media expert validators and material expert validators and conducted practicality tests on 28 students. Data analysis is performed using a likert scale. The resulting product is a guide book practicum of respiratory system materials in humans. Based on the results of expert validation, the material obtained a score of 3.73 or 93.25% with a very valid category and the validation of media experts obtained a score of 3.15 or 78.75% with a valid category. While the student user's response to the development of practicum guide books obtained a score of 3.4 or 85% with a very practical category. Thus, media that has been declared valid and practical through a test, it can be used well as a practicum guide.
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