Background: Insertion of peripheral intravenous cannulation during hospitalization can cause anxiety and pain in preschool children. Anxiety in children due to the installation of peripheral intravenous cannulation can result in fear, discomfort, and non-cooperation, which can have a bad impact on the child's psychological and physiological condition. Unresolved pain can result in traumatic experiences for children. One distraction technique that can be applied to overcome anxiety and pain is medical play. Objective: The research aimed to analyze the effect of medical play on anxiety and pain in preschool-aged children when undergoing peripheral intravenous cannulation. Methods: This research used a quasi-experimental pre and post-test with a control group design involving 31 control group respondents and 31 intervention respondents. The respondent selection was carried out using consecutive sampling techniques. Univariate and bivariate data analysis used dependent and independent t-tests. Results: The results of the study showed that there was a difference in the average anxiety score with a value of p= 0.001 in the intervention and control groups. There was no difference in mean pain scores with a p-value of 0.528 in the intervention and control groups. There was no relationship between respondent characteristics and anxiety and pain when installing peripheral intravenous cannulation. Conclusion: This study recommends that medical play can reduce anxiety in preschool children when peripheral intravenous cannulation is installed.
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