<![CDATA[Coronavirus disease 2019 (COVID-19) is an infection caused by SARS-CoV-2. The course of the disease often has more severe clinical symptoms if accompanied by a bacterial infection, known as co-infection or secondary bacterial infection. Apart from having a clinical impact, it also causes the use of more antibiotics, increasing antibiotic resistance. To overcome this, we need data showing the most frequent etiologic agents of bacterial coinfection in patients with COVID-19. This systematic review aims to determine the etiologic agent of the most common secondary bacterial infection in COVID-19. This systematic review is presented based on the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) criteria. The electronic databases used for the literature search are; PubMed, ScienceDirect, CochraneLibrary, and Google Scholar. Keywords used in the electronic database are described using Boolean operators as follows: (("SARS-CoV-2 Infection" OR "Coronavirus Disease 19" OR "COVID-19") AND ("Secondary Bacterial Infection" OR "Bacterial Co-infection”)). All literature was selected taking into account the eligibility criteria and reference standards. The protocol of this review has been registered in International Prospective Register of Systematic Reviews (PROSPERO) with the registration number is CRD42022331998. Eleven studies were included in the qualitative synthesis. The results of the study showed that Gram-negative bacteria were the most common etiologic agents. These bacteria include Escherichia coli, Klebsiella pneumonia, and Pseudomonas aeruginosa. This systematic review provides valuable evidence of the most frequent etiologic agents of secondary bacterial infection in COVID-19 patients.]]>
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