Patients with chronic kidney disease undergoing hemodialysis face significant changes in their daily lives, both physically and psychosocially. The process of adapting to this long-term therapy is not always easy and, in many cases, is an important factor affecting patients' quality of life. This study aims to examine the relationship between hemodialysis duration and quality of life in patients undergoing hemodialysis. The study used a cross-sectional correlational quantitative design involving 89 patients undergoing routine hemodialysis. Data collection was conducted using the World Health Organization Quality of Life (WHOQOL) questionnaire, and the data were analyzed using Spearman's correlation test. The results showed a significant positive relationship between patient adaptation and quality of life. Patients with better adaptation abilities tended to report a higher quality of life. These findings emphasize the important role of nursing in supporting the patient's adaptation process through a holistic, continuous care approach. Efforts to strengthen patient adaptation can improve the well-being and quality of life of individuals with chronic kidney disease undergoing hemodialysis
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