<![CDATA[Fatigue among patients undergoing hemodialysis is a multifactorial symptom resulting from complex physiological and psychological mechanisms. One important factor associated with fatigue is the patient's level of physical activity. Most individuals undergoing hemodialysis tend to reduce their physical activity because they experience rapid exhaustion, muscle weakness, or fear that physical exertion may worsen their health condition. This study used a quantitative research design, a descriptive correlational approach with a cross-sectional design. A total of 44 patients fulfilled the inclusion criteria and participated in the study. Data were collected using a structured questionnaire comprising three sections: physical activity and fatigue. The results show a significant relationship between physical activity and fatigue among patients undergoing hemodialysis. This finding is consistent with the concept of physiological adaptation in patients with chronic kidney disease, whereby regular physical activity helps preserve skeletal muscle function, improve cardiorespiratory capacity, enhance energy metabolism, and mitigate the decline in functional capacity associated with long-term hemodialysis therapy.]]>
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