<![CDATA[Urine sediment examination supports the diagnosis and monitoring of kidney and urinary tract disorders. One pre-analytical factor that can potentially affect the accuracy of urine sediment examination results is variation in urine specimen volume. This study aims to analyze the effect of urine volume variation on crystal findings in urine sediment examination. This study used an experimental design with 30 urine specimens from patients undergoing complete urine examination. Urine specimens were treated in three volume variations, namely twelve milliliters, eight milliliters, and five milliliters, then microscopic examination of urine sediment was performed to identify crystal findings. The data were analyzed using comparative statistical methods to assess differences in crystal findings across urine volumes. The results showed that urine volume variation significantly affected the number of crystals detected, with a tendency for fewer crystals as urine volume decreased. A higher urine volume resulted in greater crystal detection sensitivity than a lower one. These findings emphasize the importance of controlling pre-analytical factors, particularly urine volume, in urine sediment examination. Therefore, clinical laboratories need to establish minimum urine volume standards to improve the reliability of examination results. ]]>
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