<![CDATA[Chronic kidney failure is a progressive condition characterized by a decline in kidney function, leading to an inability to eliminate metabolic waste from the body. Hemodialysis is used as a renal replacement therapy to assist in the blood cleansing process and maintain the patient's physiological balance. This study aims to analyze differences in serum creatinine levels in patients with chronic kidney failure before and after undergoing hemodialysis at the Bali Husada Cipta Canthi Clinic in Denpasar City. The study used an analytical observational design with a cross-sectional approach to 18 patients with end-stage chronic kidney failure, selected through total sampling. Serum creatinine levels were obtained from laboratory tests before and after a single hemodialysis session. The analysis used a paired sample t-test. The results showed a decrease in serum creatinine levels after hemodialysis compared with pre-procedure levels. It indicates the therapy's effectiveness in reducing the accumulation of metabolic waste in the blood. However, post-hemodialysis creatinine levels remained above normal reference values, reflecting the limitations of hemodialysis in entirely replacing kidney function. These findings emphasize the importance of monitoring serum creatinine as a clinical indicator of therapeutic response. Patients with chronic renal failure need to undergo hemodialysis consistently and continuously.]]>
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