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p-Index From 2021 - 2026
0.61
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All Journal Medical Laboratory Science Journal
Didik Prasetya
STIKES Wira Medika Bali, Indonesia

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Hemoglobin levels before and after hemodialysis in patients with chronic kidney disease Ni Wayan Dian Pebrianti; Didik Prasetya; Sri Idayani
Medical Laboratory Science Journal Vol. 1 No. 2 (2025): November 2025
Publisher : Kadewa Bakti Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.67958/medlab.v1i2.61

Abstract

Chronic kidney disease refers to a progressive condition characterized by an irreversible decline in kidney function and generally requires hemodialysis therapy. This therapy can affect hemoglobin levels, which play an important role in oxygen transport and metabolic balance. This study aims to describe hemoglobin levels before and after hemodialysis in patients with chronic kidney disease. The study is a descriptive quantitative approach with a sample of 30 patients undergoing routine hemodialysis, selected using total sampling. Venous blood samples were collected before and after hemodialysis and analyzed using an automated hematology analyzer based on electrical impedance. The data were analyzed descriptively to characterize the distribution of hemoglobin levels and changes in hemoglobin levels during hemodialysis. The results indicated that most patients had hemoglobin levels below the reference value both before and after hemodialysis, with a tendency to decrease after hemodialysis. This pattern was observed across age groups and genders, suggesting that hemodialysis may contribute to changes in hemoglobin levels. These findings emphasize the importance of routine hematological monitoring in hemodialysis patients as part of clinical laboratory services to support early detection and management of anemia in chronic kidney disease.
Difference in creatinine levels before and after hemodialysis in patients with chronic kidney disease I Komang Nuriasa; Sri Idayani; Didik Prasetya
Medical Laboratory Science Journal Vol. 1 No. 2 (2025): November 2025
Publisher : Kadewa Bakti Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.67958/medlab.v1i2.65

Abstract

Chronic kidney failure is a progressive condition characterized by a decline in kidney function, leading to an inability to eliminate metabolic waste from the body. Hemodialysis is used as a renal replacement therapy to assist in the blood cleansing process and maintain the patient's physiological balance. This study aims to analyze differences in serum creatinine levels in patients with chronic kidney failure before and after undergoing hemodialysis at the Bali Husada Cipta Canthi Clinic in Denpasar City. The study used an analytical observational design with a cross-sectional approach to 18 patients with end-stage chronic kidney failure, selected through total sampling. Serum creatinine levels were obtained from laboratory tests before and after a single hemodialysis session. The analysis used a paired sample t-test. The results showed a decrease in serum creatinine levels after hemodialysis compared with pre-procedure levels. It indicates the therapy's effectiveness in reducing the accumulation of metabolic waste in the blood. However, post-hemodialysis creatinine levels remained above normal reference values, reflecting the limitations of hemodialysis in entirely replacing kidney function. These findings emphasize the importance of monitoring serum creatinine as a clinical indicator of therapeutic response. Patients with chronic renal failure need to undergo hemodialysis consistently and continuously.
Effect of room-temperature storage duration of assayed serum control on total bilirubin quality control Syntia Ellen Venty Gosal; Putu Gede Subhaktiyasa; Didik Prasetya
Medical Laboratory Science Journal Vol. 2 No. 2 (2026): November 2026
Publisher : Kadewa Bakti Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.67958/medlab.v2i2.105

Abstract

Internal quality control is an important process to ensure the quality of laboratory test results. Assayed serum control monitors examination accuracy and precision; however, room-temperature storage may affect analyte stability. This study aimed to determine how room-temperature storage duration affects the reliability of total bilirubin quality control. This experimental study used repeated measurements of normal and pathological serum samples at 0, 4, and 8 hours of storage. We evaluated results using the coefficient of variation (CV), bias, total error (TE), Levey-Jennings charts, and Westgard rules. Data were analyzed using Repeated Measures ANOVA. Results showed that storage duration significantly affected total bilirubin at the normal level (p=0.009) and the pathological level (p<0.001). All CV values met the acceptance criteria (<5%), and TE values remained below TEa. Levey-Jennings evaluation showed that quality control results remained within control limits at the normal level but were rejected (out of control) at the pathological level from 4 hours onward. Despite this loss of statistical control, total error remained below the allowable total error (TEa) threshold at both levels throughout the 8 hours, indicating that Westgard control status and total error assess different, complementary aspects of analytical quality. Storage duration affected total bilirubin quality control reliability, particularly at the pathological level, and acceptable storage duration should be judged by control level and QC criteria rather than a single uniform time limit.
Co-Authors I Komang Nuriasa Ni Wayan Dian Pebrianti Putu Gede Subhaktiyasa Sri Idayani Syntia Ellen Venty Gosal