<![CDATA[Introduction: Diabetes constitutes a metabolic anomaly influencing glucose utilization within the body, and the susceptibility to diabetes is heightened among menopausal women as a consequence of hormonal fluctuations. Flavonoids, natural compounds found in various plant-based products, have shown antidiabetic properties. This study aims to explore the effectiveness of flavonoids as a therapy for diabetes in menopausal women. Methods This study used electronic databases searching and blood glucose levels were extracted from the selected articles for analysis. Two primary studies included: Sideritis scardica 70% ethanolic root extract and Argimonia pilosa Ledeb. Aqueous leaf extract in ovariectomized (OVX) rats. Results: Flavonoids extracted from S. scardica and A. pilosa demonstrated a notable decrease in blood glucose levels among the OVX diabetes group in comparison to the control group. Flavonoids have multiple mechanisms of action, including reducing glucose absorption, increasing glucose tolerance, and enhancing insulin receptor sensitivity. They also act as antioxidants and have estrogenic effects. Both S. Scardica and A. pilosa show outstanding excellence as natural remedies for managing diabetes in postmenopausal women. Based on the results of this meta-analysis, the two flavonoid-containing plants containing flavonoids significantly reduced blood glucose in OVX rats in the experimental group (P<0.05). Conclusion: further research can be carried out with clinical trials on the potential of S. scardica and A. pilosa flavonoids to diabetes mellitus (DM) in reduce blood glucose levels in postmenopausal women with diabetes mellitus (as a therapy for metabolic disorders.]]>
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