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All Journal Asian Journal of Fertility, Endocrinology, and Reproduction
Sutrisno Sutrisno
Department of Obstetric and Ginecology, Faculty of Medicine, Brawijaya University/Saiful Anwar General Hospital, Malang, East Java, Indonesia.
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Social Sciences

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The Impact of Flavonoids on Diabetes Therapy in Menopausal Women Dyah Ayu Septika Wijaya; Sutrisno Sutrisno
ASIAN JOURNAL OF FERTILITY ENDOCRINOLOGY AND REPRODUCTION Vol. 1 No. 1 (2026): January 2026
Publisher : Malang Reproductive Training Center

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66060/ajfer.v1i1.3

Abstract

Introduction: Diabetes constitutes a metabolic anomaly influencing glucose utilization within the body, and the susceptibility to diabetes is heightened among menopausal women as a consequence of hormonal fluctuations. Flavonoids, natural compounds found in various plant-based products, have shown antidiabetic properties. This study aims to explore the effectiveness of flavonoids as a therapy for diabetes in menopausal women. Methods This study used electronic databases searching and blood glucose levels were extracted from the selected articles for analysis. Two primary studies included: Sideritis scardica 70% ethanolic root extract and Argimonia pilosa Ledeb. Aqueous leaf extract in ovariectomized (OVX) rats. Results: Flavonoids extracted from S. scardica and A. pilosa demonstrated a notable decrease in blood glucose levels among the OVX diabetes group in comparison to the control group. Flavonoids have multiple mechanisms of action, including reducing glucose absorption, increasing glucose tolerance, and enhancing insulin receptor sensitivity. They also act as antioxidants and have estrogenic effects. Both S. Scardica and A. pilosa show outstanding excellence as natural remedies for managing diabetes in postmenopausal women. Based on the results of this meta-analysis, the two flavonoid-containing plants containing flavonoids significantly reduced blood glucose in OVX rats in the experimental group (P<0.05). Conclusion: further research can be carried out with clinical trials on the potential of S. scardica and A. pilosa flavonoids to diabetes mellitus (DM) in reduce blood glucose levels in postmenopausal women with diabetes mellitus (as a therapy for metabolic disorders.
Utilization of Cranberries (Vaccinium Macrocarpon) in Menopausal Women With Recurrent Urinary Tract Infections: A Systematic Review and Meta-Analysis Ani Khoirinda; Sutrisno Sutrisno
ASIAN JOURNAL OF FERTILITY ENDOCRINOLOGY AND REPRODUCTION Vol. 1 No. 1 (2026): January 2026
Publisher : Malang Reproductive Training Center

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66060/ajfer.v1i1.4

Abstract

Introduction: Menopause is a condition in women who experience menstrual cessation for 12 months. The average age of menopausal women is 45 – 55 years. In comparison, early menopause occurs at <40 years. Hormonal changes are one of the characteristics of menopausal women, and these changes can affect the bladder organs, leading to an increase in vaginal pH > 5, which can lead to UTIs. Treatment is needed to prevent recurrent UTIs. Cranberry is one of the treatments that can be given and is included in phytopharmaceutical treatment. In addition, cranberries can be given to menopausal women who have a history of recurrent UTIs or are experiencing UTIs. Methods: A systematic review was used, including journal articles published on Google Scholar, ScienceDirect, and PubMed. The article used is original research. Statistical evaluation for meta-analysis using Review Manager (RevMan) v.5.4, Risk Ratio with a CI95% CI. Results: Four studies that met the inclusion criteria in the relationship of cranberry administration in menopausal women were compared to placebo; the total population in this study was as many as (n = 947). In the combined analysis of cranberry juice and placebo capsules, the incidence of rUTI was significantly lower in the cranberry group than in the placebo group (RR 0.71, 95% CI 0.57-0.89; p = 0.003). In addition, the incidence of rUTI was significantly lower in the cranberry group than in the placebo group (RR 0.74; 95% CI 0.56, 0.98; p = 0.03). Conclusion: In a double-blinded study, it was found that Cranberry administration has an influence on the incidence of rUTI in menopausal women. Cranberry juice obtained significant results in the treatment group compared to the placebo.
Flavonoid Intake and Their Effect to Against Ovarian Cancer in Menopause:  A Systematic Review and Comprehensive Meta-Analysis R.A. Rahmawati Nurul Fadilah; Sutrisno Sutrisno
ASIAN JOURNAL OF FERTILITY ENDOCRINOLOGY AND REPRODUCTION Vol. 1 No. 1 (2026): January 2026
Publisher : Malang Reproductive Training Center

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66060/ajfer.v1i1.7

Abstract

Introduction: The worst gynecologic malignancy and the fifth-leading cause of cancer-related death in women worldwide is ovarian cancer. New therapeutic agents that are more effective and less likely to cause adverse reactions are urgently needed. Although flavonoids are primarily focused on their cytotoxic anticancer activity, they may also inhibit cell migration and invasion, affect cell cycle progression or induce apoptosis in specific tumor cells. This change may be related to flavonoids and ovarian cancer. That will be discussed in this study regarding the effects of flavonoid intakes on menopausal women to prevent ovarian cancer. Methods: Systematic searches were conducted using Google Scholar, Science Direct, PubMed, DOAJ (Directory of Open Access Journals), Cochrane, and Wiley. PRISMA 2020 rules are used to filter acquired articles. Studies examining the effects of flavonoids on ovarian cancer prevention considered for evaluation. Odds ratios and 95% confidence intervals (CIs) for random-effects meta-analyses were presented. Results: It was discovered that there is a correlation between flavonoids and the incidence of ovarian cancer during menopause among five studies that satisfied the requirements for inclusion in this article (n = 3886). The treatment group given flavonoids to reduce the incidence of apoptosis in ovarian granulosa cells in menopausal rats found that flavonoids reduced ovarian granulosa cell by 0.42 times compared with the placebo group (95% CI, OR=0.42 [0.18, 0.95]; P=0.04). Similarly, an isoflavone diet in menopausal women results in 0.89 times reduction in the risk of ovarian cancer compared with the group that does not follow an isoflavone diet, with OR=0.89 (CI 95%, 0.78, 1.02; P=0.08). When the five studies compared dietary isoflavones with flavonoid derivatives for ovarian cancer incidence, they showed a 0.87 times reduction in ovarian cancer incidence with dietary isoflavones (OR=0.87; CI 95%, 0.77, 0.99; P=0.04). Conclusion: In this meta-analysis, the efficacy of flavonoids compared to placebo can be considered as a preventive measure against ovarian cancer in menopause.
The Anti-Inflammatory Effects of Genistein Inhibits Tumor Necrosis Factor-Α Receptor 1 (TNF-R1) and IL-8 Receptor (CXCR-1) Levels in Peritoneal Endometriosis Lesion of Mice Model Endometriosis Sutrisno Sutrisno; Cholid Rochman Riskianto; Yulianto Rapa; Nina Rini Suprobo; Pande Made Dwijayasa
ASIAN JOURNAL OF FERTILITY ENDOCRINOLOGY AND REPRODUCTION Vol. 1 No. 1 (2026): January 2026
Publisher : Malang Reproductive Training Center

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66060/ajfer.v1i1.9

Abstract

Introduction: Endometriosis is a complex condition that typically causes an inflammatory reaction in the peritoneal cavity. Tumor Necrosis Factor-α receptor 1 (TNF-R1) and IL-8 receptor (CXCR-1) are thought to play a role in the pathophysiology of endometriosis. This study evaluates the effects of genistein at various doses on the content of TNF-R1 and CXCR1 in the peritoneal endometriosis lesions in mice model of endometriosis. Methods: This experiment study, a total 32 female mice (Mus musculus) with induced endometriosis were allocated to the eight groups (n=4 per group), including a control group, endometriosis model group (EM), and six groups treated with different doses of genistein (0.13, 0.26, 0.52, 0.78, 1.04, and 1.30 mg/day) for 14 days. The peritoneal endometriosis lesion was then measured for TNF-R1 and CXCR-1 levels. Results: The level of TNF-R1 and CXCR-1 in the EM group was significantly elevated compared to the control group. Following genistein administration, TNF-R1 and CXCR-1 levels were significantly lower than in the EM group. Conclusion: Genistein has an anti-inflammatory effect, reducing TNF-R1 and CXCR-1 in mice model of peritoneal endometriosis and could be a potential treatment for endometriosis.
Co-Authors Ani Khoirinda Cholid Rochman Riskianto Dyah Ayu Septika Wijaya Nina Rini Suprobo Pande Made Dwijayasa R.A. Rahmawati Nurul Fadilah Yulianto Rapa