<![CDATA[Introduction: Endometriosis is an abnormal endometriosis growth in the outside of uterus, which performed pelvic pain and high inflammatory markers. This study investigated the potential endometriosis therapeutic agents of flavonoid compounds from P. macrocarpa in decreasing IGF-1, IL-33, IL-2, IL-10, IFN-Ɣ, and MUC1 levels in the endometriosis mice model. Methods: Forty female mice, weight 20 – 30 grams, 6 – 8 weeks old, were classified into 8 groups (Normal, Endometriosis (EM), EM +3.75; EM + 7.5; EM +11.25; EM + 15; EM + DNG; and EM + LA). Endometriosis mice models were induced by injecting cyclosporin, followed by adenomyosis tissue that was injected intramuscularly and ethynyl estradiol. Endometriosis mice were treated as group as for 14 days. The peritoneal fluid of all animal models was collected and analyzed by using ELISA. Result: Administrated of PME 7.5 mg/mice/day for 14 days increase IL-10. The PME decreased IL-2 significantly and improved the IL-2 levels as well as normal mice. PME also reduced IL17A, IGF1, IL-33 and lowered IL-4, IFN y, and Mucin1 levels. Conclusion: Phaleria macrocarpa fruit extract altered inflammation marker protein of endometriosis mice model for 14 days and potentially for endometriosis therapeutic agents.]]>
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