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All Journal Asian Journal of Fertility, Endocrinology, and Reproduction
Sutrisno Sutrisno
1 Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Social Sciences

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Flavonoids Extract of Phaleria macrocarpa Fruit Extract Ameliorated Inflammation Markers In Endometriosis Mice Models Sutrisno Sutrisno; Maharani Maharani; Gema Alya Salsabila; Ani Khoirinda; Leni Ria Ariana; Ana Paramita Prastiwi; Maria Antonia Barbara Batu Mali
ASIAN JOURNAL OF FERTILITY ENDOCRINOLOGY AND REPRODUCTION Vol. 1 No. 2 (2026): April 2026
Publisher : Malang Reproductive Training Center

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66060/ajfer.v1i2.38

Abstract

Introduction: Endometriosis is an abnormal endometriosis growth in the outside of uterus, which performed pelvic pain and high inflammatory markers. This study investigated the potential endometriosis therapeutic agents of flavonoid compounds from P. macrocarpa in decreasing IGF-1, IL-33, IL-2, IL-10, IFN-Ɣ, and MUC1 levels in the endometriosis mice model. Methods: Forty female mice, weight 20 – 30 grams, 6 – 8 weeks old, were classified into 8 groups (Normal, Endometriosis (EM), EM +3.75; EM + 7.5; EM +11.25; EM + 15; EM + DNG; and EM + LA). Endometriosis mice models were induced by injecting cyclosporin, followed by adenomyosis tissue that was injected intramuscularly and ethynyl estradiol. Endometriosis mice were treated as group as for 14 days. The peritoneal fluid of all animal models was collected and analyzed by using ELISA. Result: Administrated of PME 7.5 mg/mice/day for 14 days increase IL-10. The PME decreased IL-2 significantly and improved the IL-2 levels as well as normal mice. PME also reduced IL17A, IGF1, IL-33 and lowered IL-4, IFN y, and Mucin1 levels. Conclusion: Phaleria macrocarpa fruit extract altered inflammation marker protein of endometriosis mice model for 14 days and potentially for endometriosis therapeutic agents.
Co-Authors Ana Paramita Prastiwi Ani Khoirinda Gema Alya Salsabila Leni Ria Ariana Maharani Maharani Maria Antonia Barbara Batu Mali