Anti-Inflamatory Effect Of Aquadest Extract Of Mango Ginger Rhizome (Curcuma mangga Val) In Swiss Webster Mice (Mus musculus)

Difa Damaryan (Universitas Sriwijaya)
Masagus Muhammad Tibrani (Universitas Sriwijaya)
Riyanto (Universitas Sriwijaya, Palembang, Sumatera Selatan)

SITAWA : Jurnal Farmasi Sains dan Obat Tradisional
Vol. 4 No. 2 (2025): SITAWA : Jurnal Farmasi Sains dan Obat Tradisional

This study aims to determine the effect of aqueous extract of Curcuma mangga Val. rhizome on the anti-inflammatory response in mice (Mus musculus). The study employs an experimental method with a completely randomized design (CRD) consisting of five treatment groups: a negative control (aqueous solution), a positive control (Sodium Diclofenac 0.13 mg/kgBW), and three doses of Curcuma mangga rhizome extract (7 mg/kgBW, 28 mg/kgBW, and 56 mg/kgBW). Each treatment was administered orally 15minutes before induction with 1 % of egg white. The mice's edema volume was measuredevery hour for six hours after inflammation induction using egg white. Data were analyzed using One-Way ANOVA and Duncan's Multiple Range Test (DMRT). The One-Way ANOVA results indicated a significant effect of Curcuma mangga aqueous extract on the anti-inflammatory response, while the DMRT results showed that the 56 mg/kgBW dose had the most significant anti-inflammatory effect, with an edema inhibition percentage of 63%, closely approaching the effectiveness of Sodium Diclofenac at 62%.