<![CDATA[Background: The performance of health personel is one of the biggest reasons for the good and bad health services. There are various factors that can affect employee performance such as motivation, stress, and work fatigue. This study aims to see if there is an effect of motivation, stress, and fatigue on the performance of Puskesmas employees. Subjects and Method: This study is a quantitative study using a cross-sectional design. This study was conducted on 17 health centers in the city of Surakarta, Central Java, Indonesia starting from August to September 2024. With a sample of 202 health center employees who were randomly selected or using a simple random sampling. The dependent variable in this study is the performance of health center employees. The independent variables in this study were motivation, stress, and fatigue. Data collection was carried out using a questionnaire and analyzed with path analysis. Results: Motivation has an influence on improving performance and is statistically significant. Motivation (b= 1.14; CI 95% = 1.06 to 1.06; p<0.001), stress (b= 0.83; CI 95% = 0.70 to 0.95; p<0.001), has a statistically significant effect on performance degradation, and fatigue (b=0.06; CI 95% = 0.02 to 0.12; p=0.041), had a degrading effect and was statistically significant. Conclusion: The performance of health center employees is influenced by motivation, stress, and fatigue.]]>
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