Background: Patient safety is an event where the hospital builds patient care to be safer, including risk assessment, identifying, and managing matters related to patient risk, reporting and analyzing incidents, learning from incidents and their follow-up, as well as providing solutions to reduce the occurrence of risks and to avoid injuries caused by mistakes that occur due to doing an action or taking an action that should not have been taken. The purpose of this study is to identify the behavioral determinants of patient safety practices among nurses at Dr. Moewardi Hospital, Indonesia. Subjects and Method: This study was a cross-sectional study conducted at Dr. Moewardi Hospital in January 2025. The sample consisted of 200 inpatient nurses selected by a simple random sampling method. The independent variables in this study were work attitude, work stress, communication, teamwork, and work environment. The dependent variable was the patient safety practice behavior. Data collection was conducted using a questionnaire. Data analysis was conducted using path analysis. Results: The behavior of patient safety practice in inpatient nurses was directly influenced by positive work attitudes (b=0.22; 95% CI= 0.08 to 0.36; p= 0.002), low work stress (b= 0.16; 95% CI= 0.02 to 0.30; p= 0.022), and effective communication (b= 0.24; 95% CI= 0.11 to 0.36; p<0.001). The patient safety practice behavior among nurses through work attitudes was indirectly influenced by work stress and teamwork. The patient safety practice behavior among nurses through work stress is indirectly influenced by teamwork and the work environment. The patient safety practice behavior among nurses through communication was indirectly influenced by teamwork. Conclusion: The patient safety practice behavior among inpatient nurses is directly influenced by positive work attitudes, low work stress, and effective communication. The patient safety practice behavior among nurses through work attitudes is indirectly influenced by work stress and teamwork.
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