The digital era has opened new horizons for entrepreneurs in pioneering and developing businesses. This article aims to comprehensively examine the application of the concept of entrepreneurship in the context of digital entrepreneurship, encompassing relevant strategies, opportunity identification, and challenges faced. The method used is a systematic literature review analyzing various current scientific and practical sources. The study results indicate that the success of entrepreneurs in the digital era is largely determined by the ability to adapt to technology, mastery of the digital ecosystem, and the development of a sustainable, innovative mindset. Furthermore, the utilization of digital platforms, data analytics, and artificial intelligence are key strategies that differentiate successful entrepreneurs from unsuccessful ones. Key challenges include the acceleration of technological change, increasingly fierce global competition, cybersecurity, and limited access to capital and digital infrastructure. This article provides both an academic contribution and a practical guide for aspiring entrepreneurs seeking to optimally capitalize on opportunities in the digital era
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