This study aimed to analyze the effect of health learning using pictorial posters and demonstrations on kindergarten children's knowledge of proper handwashing and safe medicine use. A pre-experimental study with a one-group pretest–posttest design was conducted involving 17 children aged 5–6 years from a kindergarten in Kediri City, East Java, Indonesia. The learning activities were based on the Contextual Teaching and Learning (CTL) approach. Data were collected using a pictorial instrument that had undergone content review and were analyzed descriptively and using the Wilcoxon Signed-Rank Test. The mean knowledge score increased from 2.29 ± 0.99 to 7.53 ± 0.72. A significant difference was found between pretest and posttest scores (Z = −3.682; p < 0.001) with a large effect size (r = 0.893). Health learning using pictorial posters and demonstrations effectively improved children's knowledge of proper handwashing and safe medicine use and has the potential to support health literacy development in early childhood education.
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