<![CDATA[Acute Lymphoblastic Leukemia (ALL) is the most common childhood cancer requiring long-term chemotherapy, which is often associated with various side effects that may reduce children's quality of life. Limited caregiver knowledge in managing chemotherapy-related side effects highlights the need for mobile-based educational interventions; however, their effectiveness requires further evaluation. Methods a quasi-experimental study with a pretest–posttest control group design was conducted among 33 caregivers of children with Acute Lymphoblastic Leukemia at Harapan Kita Women and Children Hospital, Jakarta. The intervention group received education through the N-Care LLA mobile application for four weeks, while the control group received the hospital's standard education. Caregivers' knowledge was assessed using the Homecare Parent Knowledge Questionnaire (HOPE-CKQ), and children's quality of life was measured using the Pediatric Quality of Life Inventory (PedsQL™) Cancer Module. Data were analyzed using paired t-tests, independent t-tests, and multiple linear regression. Results caregiver knowledge in the intervention group increased significantly from 11.00 ± 3.18 to 13.88 ± 3.63 (p = 0.011), whereas no significant change was observed in the control group (p = 0.789). The improvement in knowledge scores was significantly greater in the intervention group than in the control group (p = 0.031). Although children's quality of life improved in the intervention group, the difference compared with the control group was not statistically significant (p = 0.723). Multivariate analysis indicated that baseline caregiver knowledge was a significant predictor of post-intervention knowledge (p = 0.013).Conclusion the N-Care LLA mobile application was effective in improving caregivers' knowledge; however, it did not demonstrate a statistically significant improvement in children's quality of life after the four-week intervention.]]>
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