<![CDATA[Background: Diabetic ulcers are a chronic complication of diabetes mellitus that contribute significantly to morbidity, amputation risk, and healthcare system burden. Optimal glycemic control plays a crucial role in wound healing. Systemic insulin therapy is a key strategy for glycemic control, with various regimens used in clinical practice. Purpose: To determine the relationship between systemic insulin therapy and glycemic control on the healing of diabetic foot ulcers. Methods: This systematic review was compiled based on the PRISMA 2020 guidelines. A literature search was conducted on PubMed, ScienceDirect, OpenAlex, the Cochrane Library, and Google Scholar. Inclusion criteria included studies in diabetic patients with ulcers that used systemic insulin as an intervention and reported outcomes related to wound healing. Article selection, data extraction, and risk of bias assessment were conducted systematically according to the study protocol. Results: Most studies have shown a link between better glycemic control, including in patients receiving systemic insulin therapy, and improved wound healing. Several studies have reported increased wound healing rates, improved granulation tissue formation, and reduced wound complications in patients receiving insulin therapy. Conclusion: Available evidence suggests an association between systemic insulin therapy, improved glycemic control, and improved healing outcomes in diabetic foot ulcers. However, interpretation of the results is inconsistent. Some studies evaluate insulin therapy directly, while others evaluate glycemic control as a factor associated with wound healing. Keywords: Diabetes Mellitus; Diabetic Foot Ulcer; Systemic Insulin Therapy; Systematic Review; Wound Healing.]]>
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