<![CDATA[Procedural sedation is used to enhance patient comfort and the success of medical procedures. Midazolam and propofol are the most commonly used sedative agents, each with a distinct safety profile. The objective of this study is to compare the safety profiles of midazolam and propofol in the context of medical procedures. This study employs a systematic literature review approach based on the PRISMA guidelines. The literature search was conducted via PubMed, ScienceDirect, and Google Scholar from 2015 to 2025. The analyzed articles included randomized controlled trials (RCTs) and cohort studies. Methodological quality assessment was performed using an instrument from the Joanna Briggs Institute (JBI). A total of 16 studies involving more than 1,000 patients were analyzed. Propofol demonstrated a higher procedure success rate (90.9%) compared to midazolam (83.3%). However, propofol was associated with a higher risk of hypotension (31.5%) and bradycardia (17.1%). On the other hand, midazolam was more hemodynamically stable but had a longer duration of sedation. Propofol is superior in achieving procedural success but carries a higher risk of hemodynamic disturbances. Midazolam demonstrates better stability but is less superior in terms of sedation effectiveness and carries a higher risk of neurological complications and mortality.]]>
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