Background Neonatal asphyxia is one of the leading causes of neonatal mortality. Prompt and appropriate management involves the administration of positive pressure ventilation (PPV) as soon as possible, ideally within the first minute of life (the "golden minute"). Delayed administration of PPV can lower the infant's Apgar score and increase the risk of complications. Aim The aim of this study was to examine the relationship between the timing of positive pressure ventilation and Apgar scores in asphyxiated neonates. Method This study employed a descriptive-analytic method with a cross-sectional approach to investigate the relationship between the timing of PPV and Apgar scores in asphyxiated neonates. The study population consisted of all neonates with asphyxia admitted to the NICU of Jailolo General Hospital from February to July 2025, totaling 52 infants. The sampling technique used was total sampling. The research instrument consisted of a secondary data observation sheet, prepared based on the medical record format for asphyxiated neonates in the NICU of Jailolo General Hospital. Result The results showed that, among the 52 asphyxiated neonates studied, the majority received PPV within less than one minute after birth (59.6%), while 40.4% received PPV after more than one minute. Conclusion Neonates who received positive pressure ventilation within the first minute of life had better Apgar scores compared to those who received ventilation after one minute.
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