This study aims to examine the effects of e-commerce and business knowledge on new business establishment and their subsequent impact on business income among members of the Women’s School in West Java. A total of 100 members were selected as research respondents using a purposive sampling method. The data were analyzed using path analysis. The findings indicate that: (1) e-commerce and business knowledge simultaneously have a significant effect on new business establishment; (2) e-commerce has a significant partial effect on new business establishment; (3) business knowledge has a significant partial effect on new business establishment; (4) new business establishment has a significant effect on business income; (5) e-commerce and business knowledge simultaneously have a significant effect on business income; (6) e-commerce has a significant partial effect on business income; (7) business knowledge has a significant partial effect on business income; (8) e-commerce and business knowledge simultaneously have a significant effect on business income through new business establishment; (9) e-commerce has a significant effect on business income through new business establishment; and (10) business knowledge has a significant effect on business income through new business establishment.
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