<![CDATA[Injectable platelet-rich fibrin (i-PRF) is a liquid autologous platelet concentrate that may enhance periodontal healing and facilitate the delivery of graft particles or locally administered drugs. This systematic review evaluated the clinical and biological effectiveness of i-PRF for periodontal regeneration and compared it with conventional therapy and other regenerative materials. Following PRISMA 2020, Google Scholar, PubMed, and the Cochrane Library were searched for controlled human, in vivo, and in vitro studies published from 2018 to 2025. Fourteen studies met the eligibility criteria: 12 human clinical studies, one animal study, and one in vitro study. Adjunctive i-PRF generally improved probing pocket depth, clinical attachment level, bleeding indices and radiographic defect fill when combined with scaling and root planing, minimally invasive surgery, open-flap debridement or bone grafts. Reported clinical improvements included PPD reductions of approximately 2.80 - 4.20 mm and CAL gains of approximately 2.40 - 3.80 mm. Experimental evidence also supported anti-inflammatory activity, osteogenic responses and favorable cytocompatibility. No major safety concerns were reported. i-PRF is a promising and practical adjunct for periodontal regeneration, but standardized preparation protocols, larger samples, longer follow-up, and direct comparative trials are warranted before universal superiority can be concluded.]]>
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