<![CDATA[Reactive oxygen species (ROS) cause oxidative stress, damage skin architecture and collagen synthesis, and accelerate premature aging. Due to limited endogenous antioxidant defenses, external natural antioxidants such as dewandaru (Eugenia uniflora L.) leaf extract are needed, yet their use remains limited. This study develops and evaluates an antioxidant serum formulated from dewandaru leaf extract as an innovative anti-aging skincare solution that promotes local biodiversity. The research methodology involves a laboratory experiment that includes extracting dewandaru leaves with 96% ethanol and preparing serum formulations at two concentrations: F1 (5%) and F2 (7.5%). Physical tests (organoleptic, homogeneity, spreadability, viscosity, adhesion) showed that both formulations met SNI standards. Antioxidant activity using the DPPH method showed IC50 values of 94.13 ppm for F1 (strong) and 48.20 ppm for F2 (very strong). Statistical analysis indicated a significant difference (P < 0.005) between formulations. In conclusion, dewandaru leaf extract was successfully formulated into a serum with antioxidant activity, with F2 (7.5%) demonstrating the highest efficacy, classified as very strong, and potential as an agent to prevent premature skin aging. Keywords: Dewandaru leaf extract, Antioxidant, Serum, Skin Aging, DPPH.]]>
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