This study examines the relationship between excise tax burden, capital structure, and profitability in four cigarette subsector companies listed on the Indonesia Stock Exchange (IDX) during 2020–2024. A quantitative associative approach was employed using secondary data from company annual financial reports. The data were analyzed using panel data regression with EViews 12 and a Random Effect Model (REM). The results show that excise tax burden is not significantly associated with profitability (p = 0.3652), whereas capital structure has a significant positive association with profitability (p = 0.0145). The F-test indicates that excise tax burden and capital structure are jointly significant in relation to profitability (F = 6.297094; p = 0.022771). These findings highlight the different statistical relationships of the two independent variables with profitability during the observation period
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