This research is motivated by the challenge of strengthening students' leadership spirit at PTKIS Kopertais Region XII Riau-Kepri, where many students lack confidence in taking the initiative and actively participating. The aim of the research is to analyze the influence of the Islamic Social Entrepreneurship (ISE) approach on strengthening students' leadership skills and identify supporting and inhibiting factors. Quantitative methods with survey techniques using Likert scale questionnaires were applied to a sample of students selected at simple random. Research findings reveal that the ISE approach has a significant effect in strengthening leadership, reflected in the ability to make decisions based on social impact (81.9%), confidence in leading a team (72.8%), and increased social responsibility (90.9%). However, ISE implementation still faces challenges in the form of limited funds (63.7%), time (63.7%), and low training participation (36.4%). Based on These findings recommend integrating ISE courses in the curriculum, providing special funding schemes, developing sustainable training programs, and more intensive technical assistance to create an ISE ecosystem that is conducive to the formation of leadership with character and social orientation.
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