<![CDATA[Background: Adenoid cystic carcinoma (ACC) is an uncommon malignant epithelial neoplasm that most frequently arises from the salivary glands but may rarely occur in the nasal cavity and paranasal sinuses. Its diagnosis can be challenging because of its slow-growing nature, variable clinical presentation, and distinctive histopathological features. Case Presentation: A 41-year-old woman presented with a progressive nasal mass accompanied by unilateral nasal obstruction and intermittent epistaxis. Physical examination revealed a friable mass occupying the nasal cavity. An excisional biopsy was performed for histopathological evaluation. Microscopic examination demonstrated an infiltrative epithelial neoplasm composed of relatively uniform basaloid cells arranged in cribriform, tubular, and solid patterns. The cribriform areas contained pseudocystic spaces filled with eosinophilic basement membrane-like material. The tumor cells showed hyperchromatic nuclei with scant cytoplasm and mild-to-moderate cytological atypia. Perineural invasion was identified. Conclusion: Adenoid cystic carcinoma of the nasal cavity is a rare malignancy that should be considered in the differential diagnosis of an infiltrative nasal mass, particularly when histology demonstrates a characteristic cribriform or tubular architecture with pseudocystic spaces.]]>
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