Abstract: Carpal tunnel syndrome (CTS) is a neuropathy disorder commonly observed in workers who engage in repetitive and high-intensity hand or wrist movements, such as cutting, sewing, gluing, or pressing. Prolonged exposure to these activities can increase pressure on the median nerve, leading to symptoms of pain, tingling, numbness, and hand weakness.Case Report: A 31-year-old woman worked as a production operator in the stock fitting department of a footwear factory for 11 years, presented with tingling, numbness, and weakness extending from the wrist area to the fingers of both hands, especially affecting the thumb, index finger, and middle finger. These symptoms had progressively worsened over the past three months. Her job involved a rotational workflow requiring repetitive hand movements combined with physical exertion. Due to increasing discomfort and functional impairment, she had been unable to work for the past two weeks. Although right-handed, she frequently used her left hand for work-related tasks.Discussion: Occupational CTS in footwear factory workers is commonly associated with prolonged repetitive hand and wrist movements. Clinical examination revealed tingling, numbness, and weakness in the affected areas, particularly in the first three digits. Tinel’s and Phalen’s tests were positive, supporting the diagnosis of CTS. Occupational CTS was establish using the seven-steps occupational diagnosis method outlined by the Indonesian Association of Occupational Medicine Specialists (PERDOKI). This approach considers clinical assessment, occupational exposure history, work-related and non-work-related risk factors.Conclusion: Occupational CTS can be effectively diagnosed using a structured occupational diagnostic approach. Preventive measures, including administrative controls such as task rotation, ergonomic workplace adjustments, and worker education on proper hand positioning, are essential to mitigate the risk of occupational CTS among workers engaged in repetitive manual tasks. Keywords: Carpal Tunnel Syndrome (CTS), Repetitive Strain Injury (RSI), Median Nerve Compression, Ergonomic Interventions, Occupational diagnosis,
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