Hospital operational activities within 24 hours with the high workload, make a shift work system as an integral part of its services. Health professional nurses who work night shifts are at risk of sleep disorders. Disruption of circadian rhythms that occur on an ongoing basis has an impact on health, productivity, and overall quality of life. Quality of life is assessed based on individual perceptions of aspects of physical health, psychology, social relationships, and environment. This study aimed to identify the relationship between sleep disturbances and quality of life in working shift nurses. A cross-sectional study was conducted at Banten District Hospital. The research subjects included 130 nurses with a stratified random sampling technique. Primary data were obtained by filling out demographic characteristics, the Pittsburgh Sleep Quality Index (PSQI), and WHO Quality Of Life – Bref (WHOQOL-Bref) questionnaire. Bivariate analysis was performed with a chi-square statistical test. The results showed that most nurses experienced sleep disturbances (68.5%) and were included in the category of good quality of life (75.4%). There was no significant relationship between sleep disorder and quality of life for shift-working nurses at Banten District Hospital (p = 0.632).
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