Advances in digital technology are driving innovation in more interactive learning media that meet the needs of 21st-century students. One medium with the potential to support biology learning is the interactive flipbook-based e-booklet. This article aims to examine the potential of flipbook-based interactive e-booklets as a biology learning medium through a literature review. The method applied in this research is a literature review by analyzing various relevant library sources, including 10 articles published between 2022 and 2026 that meet the criteria in accordance with the research objectives. Research findings indicate that the interactive flipbook-based e-booklet developed across various studies achieved an average validity level ranging from 85% to 98.19% in terms of content feasibility, language, presentation, and graphics, as well as an average practicality level between 84% and 97.73%. These results demonstrate that the interactive flipbook-based e-booklet meets the criteria for validity and practicality, making it suitable for use as a biology learning medium. Consequently, this study provides a scientific foundation that the interactive flipbook-based e-booklet is a valid and practical alternative for biology education, supporting more effective and meaningful learning.
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