Journal Pharmasci (Journal of Pharmacy and Science)
Vol. 9 No. 2 (2024): Journal Pharmasci (Journal of Pharmacy and Science)

Potential Drug Interactions in Patients with Type II Diabetes and Concomitant Hypertension in Mangusada Hospital Badung: Potensi Kejadian Interaksi Obat pada Pasien Diabetes Tipe II dengan Komorbid Hipertensi di RSD Mangusada Badung

Putu Dian Marani Kurnianta (Sekolah Tinggi Farmasi Mahaganesha)
Oni Kurniawan (Sekolah Tinggi Farmasi Mahaganesha)
Anak Agung Ngurah Putra Riana Prasetya (Sekolah Tinggi Farmasi Mahaganesha)



Article Info

Publish Date
26 Jul 2024

Abstract

Patients with type II diabetes may experience complications such as hypertension of which the incidence is quite high in Indonesia, including Bali. Management of both conditions usually involves antidiabetic and antihypertensive agents simultaneously. This study aimed to calculate the incidence of potential drug interactions in patients with type II diabetes and concomitant hypertension at the Mangusada Hospital Badung. This study was conducted under observational cross-sectional design during September 2022-August 2023. Inclusion criteria were type II diabetes outpatients with hypertension aged ?18 years receiving not less than two types of medication and had medical record data available during the period of year 2022. The results showed that of the 68 patient’s medical records, female patients were dominating (52.94%). Meanwhile, the largest age group was >65 years (55.88%). The most frequent number of potential drug interactions were metformin and amlodipine with 43 cases (63.23%) among the total incidence in all patients being 66.17%. The most common interaction mechanisms were pharmacodynamics (63.23%) and moderate severity level (66.17%). These findings may contribute for improving patient care through the collaborative role of health practicioners, as well as developing prospective research on the aspect of actual drug interactions and relevant treatments in the future.

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Journal Info

Abbrev

jps

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

Description

Journal of Pharmacy and Science (Pharmasci) publishes full-length original articles and reviews. The scope of the journal is pharmaceutical and basic science, including its research and application. The editors, therefore, welcome contributions on the following topics: 1. Clinical pharmacy 2. ...