<![CDATA[Endophytic microorganisms colonize the internal tissues of host plants without causing apparent disease symptoms and are recognized as promising sources of structurally diverse secondary metabolites with potential pharmacological activities. Medicinal plants may harbor endophytes capable of producing bioactive compounds with applications in drug discovery and biological control. In this study, four endophytic isolates were successfully recovered from the stem bark of Ziziphus spina-christi (bidara) and identified as Pythium longifolium (KBB11), Penicillium sp. (KBB42), Mortierella sp. (KBB421), and Colletotrichum acutatum (KBB422). Their potential antidiabetic activity was evaluated in vitro using an α-glucosidase inhibition assay. Isolates KBB11, KBB421, and KBB422 exhibited IC₅₀ values of 92.21, 93.20, and 65.65 µg/mL, respectively, and were classified as active according to the criteria applied in this study. In contrast, KBB42 showed an IC₅₀ value of 132.29 µg/mL and was classified as inactive. Among the tested isolates, KBB422 exhibited the strongest α-glucosidase inhibitory activity, as indicated by its lowest IC₅₀ value. These findings suggest that endophytic microorganisms associated with the stem bark of Z. spina-christi, particularly isolate KBB422, may represent promising sources of α-glucosidase inhibitory metabolites and warrant further investigation for their antidiabetic potential.]]>
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