<![CDATA[Osteoarthritis is a progressive degenerative joint disease characterized by the destruction of articular cartilage and diarthrodial joint structures. The aim of this study was to determine the dose of Cartiflex cream to reduce pain in knee osteoarthritis patients. The pain scale was measured subjectively using the Visual Analog Scale. The classification of Cartiflex cream dosage includes four dosage groups: 0.5 g. 1 g, 1.5 g, and 2 g. Subjects applied Cartiflex cream according to the dose given to the painful knee three times a day. On the 15th day, subjects were assessed on a pain scale in standing and lying positions while moving. The analysis, results showed that a dose of 0.5 grams cartiflex cream was proven to be able to reduce pain and did not show a significant difference compared to a dose of 2.0 grams, both in standing and lying positions on the right and left legs but had a significant difference compared to a dose of 1.0 grams in standing and lying positions on the right leg. Meanwhile, on the left leg in a standing position, no significant difference was found between the two doses. A dose of 0.5 grams shows a significant reduction in pain as well as the highest level of sensory comfort, which is important in long-term topical therapy. So, to reduce knee pain caused by osteoarthritis in subjects aged 50-60 years, 0.5 grams of Cartiflex cream can be used topically.]]>
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