<![CDATA[This study aimed to determine the relationship between knowledge levels and medication adherence among patients with diabetes mellitus in the inpatient unit of Toto Kabila Hospital, Gorontalo. A quantitative analytical observational study with a cross-sectional design was conducted involving 58 patients in July–August 2025. Knowledge was assessed using the 24-item Diabetes Knowledge Questionnaire (DKQ), while medication adherence was measured using the eight-item Morisky Medication Adherence Scale (MMAS-8). Data were analyzed using the chi-square test. The results showed that most respondents had a moderate level of knowledge (63.8%), followed by good knowledge (22.4%) and low knowledge (13.8%). Regarding medication adherence, 44.8% of respondents had moderate adherence, 37.9% had low adherence, and 17.2% had high adherence. The chi-square analysis revealed a statistically significant relationship between knowledge level and medication adherence ((\chi^2=16.005), (df=4), (p=0.003)). These findings indicate that knowledge level was significantly associated with medication adherence among patients with diabetes mellitus at Toto Kabila Hospital. However, because of the cross-sectional design, the findings do not establish a causal relationship. The results highlight the importance of patient education and medication counseling as components of diabetes management.]]>
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