The PISA test results show that Indonesia's scientific literacy is still below the international average score. This research aims to develop an ethnochemistry-based e-module with the Nature of Science (NoS) model that is valid, practical, and effective as teaching material in increasing students' scientific literacy on stoichiometry material. This research includes development research with the ADDIE model (Analyze, Design, Development, Implementation, and Evaluation). The research subjects were 5 validators and 35 students in class XI-4 of SMA Negeri 1 Banjarmasin. Data collection was carried out using questionnaires, observation sheets, and test instruments. The data was analyzed descriptively. This research shows that the e-module developed is very valid with a validity score of 97.12%, very practical with a practicality score of 93.32%, and effective with an effectiveness score of 77.17%. Learning using the developed e-module increases students' scientific literacy as indicated by the N-gain value in the high category, namely 0.77. The ethnochemistry-based e-module with the NoS model developed is feasible to increase students' scientific literacy through stoichiometric learning.
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