Integrating scientific critical thinking into learning materials can support students’ conceptual understanding, problem-solving skills, and confidence in learning chemistry. This study aimed to develop a Scientific Critical Thinking (SCT)-based e-module on buffer solutions that is valid, practical, and effective in improving students’ critical thinking skills and self-efficacy. The study employed a research and development design using a modified 4D model comprising three stages: define, design, and develop. Participants were 36 Grade XI science students at SMAN 9 Banjarmasin. Data were collected through validation and practicality sheets, student response and self-efficacy questionnaires, and critical-thinking tests. Descriptive analysis was used to assess validity and practicality, while N-gain analysis measured improvements in critical thinking skills and self-efficacy. The e-module was categorized as fairly valid, while student responses and readability indicated strong agreement. The teacher’s ability to use the e-module and manage classroom activities was rated very good. High normalized gains were observed in students’ critical thinking skills and self-efficacy. Thus, the SCT-based e-module was valid, practical, and effective for supporting chemistry learning
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