Background: Patients with heart disease may experience depressive symptoms and reduced quality of life, highlighting the need to evaluate brief psychosocial interventions in outpatient care. This study examined short-term changes in depressive symptoms and reported quality of life following a brief mindfulness-based program incorporating psychoeducation and Cardiac-Focused Breathing among cardiac outpatients at Undata Regional Hospital, Palu. Methods: A single-group pretest–posttest study involved 15 heart disease outpatients at Undata Regional Hospital, Palu, recruited consecutively. A 60-minute session comprised psychoeducation, guided Cardiac-Focused Breathing, and reflection, followed by prescribed daily home practice for two weeks. Depression and quality of life were assessed using the BDI-II and WHOQOL-BREF. Pretest–posttest comparisons used the Wilcoxon signed-rank test. Results: The reported mean depression score decreased from 23.93 ± 3.77 to 13.47 ± 4.07 (mean change, −10.46 points; p = 0.001). The reported quality-of-life score increased from 66.40 ± 4.60 to 80.27 ± 5.11 (mean change, +13.87 points; p = 0.001). Thirteen participants (86.7%) had directional changes in both outcomes. Conclusion: Lower depression scores and higher reported quality-of-life scores were observed after the program. Controlled studies with longer follow-up are needed.
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