AKTIVITAS ANALGESIK EKSTRAK ETANOL DAUN MAHKOTA DEWA (Phaleria macrocarpa (Scheff.) Boerl) SECARA IN VIVO

salman salman (Program Studi Farmasi, Fakultas Farmasi, Universitas Tjut Nyak Dhien, Medan, Indonesia)
Muharni Saputri (Fakultas Farmasi Universitas Tjut Nyak Dhien)
Ika Mustika

Journal of Pharmaceutical and Sciences.
Vol 4 No 1 (2021): JPS Volume 4 Nomor 1 (2021)

Pain is a feeling of discomfort caused by intense or destructive stimuli, which, if left untreated, can affect your daily routine. Pain can be treated with analgesics. One of the plants that are thought to have analgesic effects is the leaves of the mahkota dewa. The purpose of this study was to determine the analgesic effect and dosage of the ethanol extract of mahkota dewa leaves and to determine the effectiveness of the ethanol extract of the mahkota dewa leaves as an analgesic using the stretching method. The study began with the collection and processing of the leaves of the mahkota dewa into ethanol extract using the maceration method; then, the research was continued within in vivo analgesic activity testing of 25 mice that had been induced by pain using 1% acetic acid. The induced mice were divided into five treatment groups, where the mice in the first group served as a negative control group; in this group, they were given CMC at a dose of 0.5%. The second group of mice, which were positive controls, were given mefenamic acid at a dose of 500 mg. In contrast, in mice, the third, fourth, and fifth groups, which were the treatment group, were given ethanol extract of the leaves of mahkota dewa with consecutive doses of 0.25 g/kg BW, 0.50 g/kg BW, 0.75 g/kg BW. Parameters measuring the effectiveness of the extracts used in this study included the amount of stretching, the percentage of analgesic power, and analgesic effectiveness. The results showed that the positive control group had the highest percentage of analgesic power at 59.9%. At EEDMD 0.75 g/kg BW gained 55.5%. EEDMD at a dose of 0.25 g/kg BW obtained 46.33%. Furthermore, EEDMD at a dose of 0.50 g/kg BW amounted to 55.06%. Furthermore, the percent effectiveness showed that EEDMD 0.75 g/kg BW had the highest percentage effectiveness, namely 92.65%. Whereas at EEDMD 0.25 g/kg BW is 77.29% and in EEDMD 0.50 g/kg BW is 91.91%. Based on the results of statistical analysis using ANOVA, it was found that the ethanol extract of the leaves of the mahkota dewa dosage of 0.75 g / kg BW had analgesic activity close to 500 mg of mefenamic acid.