<![CDATA[Dyslipidemia is a lipid metabolism disorder characterized by elevated plasma lipid levels and is one of the major risk factors for cardiovascular disease (CVD). Simvastatin, a commonly prescribed statin for the management of dyslipidemia, is associated with adverse effects on muscles and the skeletal system. Beetroot (Beta vulgaris L.) and black sugarcane bagasse (Saccharum officinarum L.) extracts contain flavonoids and terpenoids, which are known to have cholesterol-lowering properties. This study aimed to compare the effects of beetroot extract and black sugarcane bagasse extract on increasing high-density lipoprotein (HDL) levels in Wistar rats fed a high-fat diet. The study employed a post-test-only control group design involving 24 male Wistar rats divided into six treatment groups for one month. Total cholesterol levels were analyzed using one-way analysis of variance (ANOVA), followed by the least significant difference (LSD) post hoc test. Following treatment, the mean HDL levels were 33.5 in the normal group receiving a standard diet, 32.5 in the negative control group (K−) receiving quail egg yolk, 37.25 in P1 (beetroot extract at 500 mg/kg body weight), 38.25 in P2 (black sugarcane bagasse extract at 250 mg/kg body weight), 35.75 in P3 (black sugarcane bagasse extract at 500 mg/kg body weight), and 38.5 in the positive control group (K+) receiving simvastatin at 10 mg/kg body weight. The ANOVA results revealed a statistically significant difference among the groups (p = 0.023). Post hoc analysis showed no statistically significant differences between the normal group and P1 or P3; K− and P3; P1 and P2, P3, or K+; P2 and P3 or K+; and P3 and K+. However, statistically significant differences were observed between the normal group and P2 or K+, as well as between K− and P1, P2, or K+. In conclusion, beetroot extract and black sugarcane bagasse extract at doses of 250 mg/kg and 500 mg/kg body weight demonstrated comparable effectiveness in increasing HDL levels in Wistar rats.]]>
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