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All Journal Jurnal RESTI (Rekayasa Sistem dan Teknologi Informasi) Jurnal Kedokteran Anatomica (Anatomica Medical Journal) JURNAL IBNU SINA BIOMEDIKA Buletin Farmatera Hasil Pengabdian Kepada Masyarakat Majalah Patologi Indonesia Jurnal Kesehatan Panrita Husada JURNAL ILMIAH MAKSITEK JURNAL ILMIAH SIMANTEK JURNAL ILMIAH KOHESI Budapest International Research in Exact Sciences (BirEx Journal) Jurnal Implementa Husada Jurnal Pandu Husada Jurnal Kesehatan Republik Indonesia JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Jurnal Pengabdian Ilmu Kesehatan
Des Suryani
UNIVERSITAS MUHAMMADIYAH SUMATERA UTARA
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PENGARUH PEMBERIAN MINUMAN BERENERGI YANG MENGANDUNG ASPARTAM TERHADAP GAMBARAN HISTOPATOLOGI CEREBELLUM TIKUS JANTAN (Rattus norvegicus L.) Ritonga, Annisa Qarunia; Suryani, Des
JURNAL IBNU SINA BIOMEDIKA Vol 1, No 1 (2017)
Publisher : UNIVERSITAS MUHAMMADIYAH SUMATERA UTARA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (374.902 KB) | DOI: 10.30596/isb.v1i1.1090

Abstract

Latar belakang. Minuman berenergi yang mengandung aspartam jika dikonsumsi secara berlebihan berpotensi merusak sel saraf, dan dapat menyebabkan kerusakan histologi cerebellum.Tujuan. Untuk mengetahui “Pengaruh Pemberian Minuman Berenergi yang Mengandung Aspartam terhadap Gambaran Histopatologi Cerebellum Tikus Jantan (Rattus norvegicus L.)”.Metode. Penelitian eksperimental dengan metode Post test Only With Control Group Design yang menganalisis histopatologi cerebellum menggunakan histoteknik parafin blok, dengan pewarnaan HE dan mikroskop cahaya serta mengumpulkan data dengan pengamatan langsung gambaran histopatologi cerebellum. Uji hipotesis menggunakan uji One-Way ANOVA yang dilanjutkan dengan uji Post Hoc Benferroni.Hasil.  Kepadatan sel purkinje normal pada uji ANOVA didapatkan  perbedaan signifikan (p=0,000). antara kontrol negatif (KN) dengan perlakuan (P1,P2) dan kontrol positif (KP1,KP2) terdapat ada perbedaan signifikan (p<0,05) dan tidak ada perbedaan signifikan (p>0,05) antara kontrol negatif (KN) dengan perlakuan (P1,P2) dan kontrol positif (KP1,KP2) dari sel purkinje yang patologis tikus jantan (Rattus norvegicus L ). Kesimpulan. Minuman berenergi yang mengandung aspartam dapat menyebabkan kerusakan berupa penurunan kepadatan sel purkinje cerebellum dan sel purkinje patologis pada kelompok perlakuan (P1,P2) dan kontrol positif (KP1,KP2). Kata kunci : Minuman berenergi, aspartam, sel purkinje, histopatologi cerebellum. 
PENGARUH PEMBERIAN EKSTRAK AIR TEBU HITAM (Saccharum officinarum L.) TERHADAP KADAR KOLESTEROL TOTAL SERUM MENCIT (Mus musculus) YANG DIINDUKSI DIET TINGGI KOLESTEROL Hidayati, Nurul; Suryani, Des
JURNAL IBNU SINA BIOMEDIKA Vol 2, No 2 (2018)
Publisher : UNIVERSITAS MUHAMMADIYAH SUMATERA UTARA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (540.058 KB) | DOI: 10.30596/isb.v2i2.2599

Abstract

AbstrakLatar Belakang. Dislipidemia adalah keadaan abnormal lipid dan lipoprotein dalam darah. Obat-obatan yang digunakan sebelumnya seperti statin, diketahui memiliki beberapa efek samping seperti myositis, kelemahan otot, insomnia, peningkatan enzim hati dan rhabdomyolysis. Octacosanol dapat menurunkan sintesis kolesterol dengan menghambat HMG-CoA reductase. Octacosanol adalah campuran alami dari alkohol jenuh rantai panjang yang dapat ditemukan di tebu, gandum, dan bekatul. Metode. Studi eksperimental, tikus dibagi menjadi 5 kelompok: kelompok kontrol negatif (diet standar), kontrol positif (diet kolesterol tinggi), dan kelompok perlakuan 1, 2 dan 3 (diet kolesterol tinggi juga 0,25 cc, 0,35 cc dan 0, 50 cc ekstrak tebu hitam). Perawatan selama 30 hari dan darah diambil pada akhir penelitian untuk pemeriksaan kadar kolesterol total serum. Hasil. Ada perbedaan yang signifikan antara kadar kolesterol total dari kelompok kontrol positif dan kelompok perlakuan, nilai p = 0,00 itu membuktikan bahwa ekstrak tebu hitam berpengaruh terhadap penurunan kadar kolesterol total tikus. Namun, hasil analisis berat badan tikus meningkat secara signifikan, nilai p = 0,00 sehingga tidak boleh diberikan pasien dengan dislipidemia dengan obesitas. Kesimpulan. Hasil penelitian ini menunjukkan bahwa pemberian ekstrak tebu hitam dapat menurunkan kadar kolesterol total serum dengan efek samping meningkatkan berat badan tikus. Kata kunci: total kolesterol, dislipidemia, octacosanol, ekstrak tebu hitam
Pengaruh Pemberian Minuman Berenergi yang Mengandung Aspartam terhadap Nilai Fungsi Ginjal Tikus Jantan (Rattus norvegicus L.) Pertiwi, Retno; Suryani, Des
Buletin Farmatera Vol 2, No 1 (2017)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (64.376 KB) | DOI: 10.30596/bf.v2i1.872

Abstract

Abstrak: Tingkat konsumsi minuman berenergi cukup tinggi di masyarakat, terutama bagi mereka yang memiliki banyak aktivitas. Minuman berenergi yang mengandung aspartam jika dikonsumsi secara berlebihan dapat mengakibatkan gangguan pada ginjal, yaitu ditandai dengan peningkatan nilai fungsi ginjal (urea dan kreatinin serum). Penelitian eksperimentaldenganmetode posttest only with control group design yang menganalisis nilai fungsi ginjal dengan menggunakan uji One Way Anova atau Kruskal-Walis. Sebelum perlakuan 30 tikus diadaptasi selama satu minggu dan dibagi kedalam lima kelompok, setelah itu tikus diberi perlakuan selama 28 hari dan pada hari ke-29 darah tikus diambil yang kemudian dilakukan pemeriksaan nilai urea dan kreatinin serum tikus.Dari uji Kruskal-Walis untuk nilai urea didapat nilai p=0,372 (p>0,05) dan  uji One Way Anovauntuk nilai kreatinin didapat nilai p=0,461 (p>0,05). dari hasil studi terdapat perubahan nilai urea dan kreatinin serum tikus namun perubahan tersebut tidak signifikan secara statistik sehingga tidak terdapat pengaruh pemberian minuman berenergi yang mengandung aspartam terhadap fungsi ginjal (urea dan kreatinin serum) pada tikus jantan (Rattus norvegicus L.)Kata Kunci :Minuman berenergi, aspartam, fungsi ginjal, urea, kreatinin. Abstract: Consumption rate of energy drinks is quite high in the community, especially for those who have a lot of activity. Energy drinks containing aspartame if consumed excessively can lead to disorders of the kidneys, which is characterized by an increase in the value of renal function (urea and creatinine serum). The experimental research with posttest only with control group design methods that analyze the value of renal function by using One Way Anova or Kruskal-Walis test. Before treatment 30 rats adapted for one week and were divided into five groups, after that the rats were treated for 28 days and on day 29 rats blood is taken and then examined values of rats urea and creatinine serum. From the Kruskal-Walis test for urea values obtained value of p=0.372 (p>0.05) and One Way Anova test for creatinine values obtained value of p=0.461 (p>0.05). From the results of the study are changes in the value of urea and creatinine serum the rats but the change was not statistically significant so there is no effect of energy drinks containing aspartame on kidney function (urea and serum creatinine) in male rats (Rattus norvegicus L.)Keyword: Energy drinks, aspartame, kidney function, urea, creatinine
Aplikasi Metode Whole Chromosome Painting untuk Mendeteksi Aberasi Kromosom pada Tumor Padat Ecie Budiyanti; Des Suryani; Jeanne Adiwinata Pawitan
Majalah Patologi Indonesia Vol 23 No 1 (2014): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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Abstract

In solid tumor, conventional cytogenetic method usualy fails to detect chromosomal aberation due to failure in obtaining good quality metaphases. Therefore, special technique is required to get the karyotype of solid tumors. Whole chromosome painting (WCP) is a method to paint the chromosomes using Fluorescence In Situ Hybridization (FISH) technique. Application of WCP, both using one and multiple colors (mFISH or SKY) or their modifications can be used to identify chromosomal aberrations, which are valuable in helping to attain a diagnosis, to determine the prognosis and management, and to predict the response to therapy. Key words: chromosomal aberation, FISH, solid tumor, whole chromosome painting.
Hubungan Kadar Low Density Lipoprotein Dengan Gangguan Pendengaran Sensorineural Nurfadhilah Amini Nasution; Muhammad Edy Syahputra Nasution; Siti Masliana Siregar; Des Suryani
Jurnal Kesehatan Panrita Husada Vol 5 No 2 (2020)
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (Stikes Panrita Husada Bulukumba)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37362/jkph.v5i2.372

Abstract

Abnormalities of lipid metabolism in hyperlipidemia are the cause of atherosclerotic plaque in the inner ear and cranial nerves VIII, which can cause sensorineural hearing loss. Based on previous research, this theory is still questionable. Objective: To determine the relationship of LDL levels with sensorineural hearing loss. Method: This study is an analytic study with a cross-sectional approach. The research sample was taken based on a categorical descriptive formula with a large sample of 38 people. The data obtained is the result of laboratory tests, physical examination of the ears, nose and throat and audiometry examination of pure tone. This research was conducted at Medan Haji General Hospital and Putri Hijau Hospital II Medan. The number of research subjects was determined using consecutive sampling techniques. Data were analyzed using chi square test statistics. Results: There was a significant correlation of LDL levels with sensorineural hearing loss with a value of p = 0.001. The highest age in this study was 50-60 years of age, the most sex was female, the highest degree of hearing loss was moderateConclusion: There is a significant relationship between LDL levels with sensorineural hearing loss. Keywords: Audiometry, Hearing Loss, Sensorineural Hearing Loss, Low Density Lipoprotein, Lipid Profile
PENGETAHUAN DAN PENERAPAN GERMAS PIS-PK PADA KELUARGA BINAAN KESEHATAN FAKULTAS KEDOKTERAN UNIVERSITAS MUHAMMADIYAH SUMATERA UTARA TAHUN 2020 HANNY RAHMI LUBIS; DES SURYANI
JURNAL ILMIAH MAKSITEK Vol 6 No 2 (2021): JURNAL ILMIAH MAKSITEK
Publisher : LP2MTBM MAKARIOZ

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Abstract

In an effort to improve the quality of health in Indonesia, the president initiated a national movement, namely GERMAS. Theimplementation of GERMAS activities starts from the family level as the smallest part of the community. In order to supportthis government movement, the UMSU Faculty of Medicine also created a program called the health assisted familyprogram. The program, which has been running since 2013, aims students to educate the target family to live healthier life.However, so far there has been no analysis of the results of this activity, both regarding the knowledge and also the dailyapplication of GERMAS PIS-PK by the assisted families. Therefore, the researcher wants to assess the knowledge andapplication of the family and see the relationship between them. To determine the relationship between the knowledge of thetarget family community on GERMAS PIS-PK and their application to the program. Observational research with crosssectional design in the health assisted families of FK UMSU class of students 2017. Research data were obtained fromprimary data using a knowledge questionnaire about GERMAS PIS-PK and a questionnaire on the application of GERMASPIS-PK. Then do the analysis with the Fisher test. There were 28 families (96.6%) with good knowledge and there were 28families (96.6%) who had applied GERMAS PIS-PK. The results of the Fisher test showed that there was a significantrelationship between the knowledge of the assisted families about GERMAS PIS-PK and the application of GERMAS PIS-PKwith a value of P = 0.034 (p <0.05). The families who have good knowledge about GERMAS PIS-PK also apply GERMASPIS-PK well in their daily life.
PERBANDINGAN EFEKTIVITAS NEFROPROTEKTOR EKSTRAK JINTAN HITAM (NIGELLA SATIVA) DENGAN EKSTRAK TEMULAWAK (CURCUMA XANTHORRHIZA) TERHADAP GAMBARAN HISTOPATOLOGI GINJAL TIKUS (RATTUS NOVERGICUS) YANG DIINDUKSI PARASETAMOL KARTIKA HANDAYANI; DES SURYANI; HUMAIRAH MEDINA LIZA LUBIS
JURNAL ILMIAH MAKSITEK Vol 6 No 2 (2021): JURNAL ILMIAH MAKSITEK
Publisher : LP2MTBM MAKARIOZ

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Abstract

Over-use of paracetamol can cause nephrotoxicity. Black cumin and curcuma contain antioxidants that can ward off freeradicals produced by paracetamol metabolism. To compare the effectiveness of nephroprotector of black cumin extract andcurcuma extract on the histopathological picture of rats induced by paracetamol. True experimental, Post Test Only ControlDesign. 24 rats were divided into 4 groups: negative control standard diet and aquades, positive group paracetamol dose500 mg / kgBB, treatment 1 extract of black cumin extract 500 mg / kgBB, and treatment 2 curcuma extract 500 mg / kgBB.After 30 minutes P1 and P2 were given a dose of paracetamol 500 mg / kg. Rats were dissected for kidney removal andhistopathological preparations were made. Degeneration, necrosis and bleeding of the proximal tubules were assessed byscoring, comparison of scores between groups was assessed by the kruskal wallis test. There were nephroprotector effectsof black cumin and curcuma, with the same effectiveness on kidney damage induced by paracetamol. Black cumin can bedeveloped further as a nephroprotector.
PENGARUH KEPATUHAN PROTOKOL KESEHATAN PANDEMI COVID - 19 TERHADAP STRES DAN RELIGIUSITAS MAHASISWA FAKULTAS KEDOKTERAN UNIVERSITAS MUHAMMADIYAH SUMATERA UTARA MUHAMMAD IQBAL; DES SURYANI; NANDA SARI NURALITA; PINTA PUDIYANTI SIREGAR
JURNAL ILMIAH MAKSITEK Vol 6 No 2 (2021): JURNAL ILMIAH MAKSITEK
Publisher : LP2MTBM MAKARIOZ

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Abstract

COVID-19 is an infectious disease outbreak that has emerged since January 30, 2019 and has been called a public healthemergency by WHO. In order to avoid community transmission, it is recommended to comply with the health protocolestablished by the government. Many of the impacts of the health protocol are felt by the community, especially students,namely academic stress. The level of adherence to the health protocol itself can be related to the level of one's religiosity.To determine the effect of compliance with the COVID-19 health protocol on stress and religiosity of students at the Facultyof Medicine, University Muhammadiyah of Sumatra Utara. This study is a cross-sectional study. The number of sampleswas calculated using the Slovin formula totaling 164 people. Hypothesis test used is Chi Square test. Data were collectedbased on a questionnaire, namely DASS-42, adherence to health protocols and the Religiosity Scale. The results showedthat during the pandemic the level of good student compliance was 52.4% and those who did not comply were 47.6% with anormal stress level of 68.3% , mild stress 15.2%, moderate stress 9.8%, heavy stress 4.9% and very severe stress 1.8%.The level of religiosity of students during the pandemic with good religiosity was 51.2% and those that were lacking were48.8%. Based on the Chi Square test, it was found that the relationship between health protocol compliance with stress (p =0.001) and religiosity (p value = 0.001) but after the Kendall's tau correlation test, the value of p = 0.001 and p = 0.001 wasfound (it seems that there is a positive relationship with very strong correlation. weak. Adherence to implementing healthprotocols has a positive correlation with religiosity and student stress, but the correlation is weak. There is a positiveinfluence between compliance with the COVID-19 protocol on stress and religiosity.
HUBUNGAN KEPATUHAN MENJALANKAN PROTOKOL KESEHATAN PANDEMI COVID - 19 DENGAN PENGETAHUAN COVID - 19 DAN PERSEPSI COVID-19 PERAWAT DI RS AVICENNA BIREUEN, KOTA BIREUEN ACEH WIDYA AFIFAH; DES SURYANI; IKHFANA SYAFINA; IKA NOPA
JURNAL ILMIAH MAKSITEK Vol 6 No 2 (2021): JURNAL ILMIAH MAKSITEK
Publisher : LP2MTBM MAKARIOZ

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Abstract

Coronavirus Disease 2019 (COVID-19) is a respiratory disease caused by Severe Acute Respiratory Disease SyndromeCoronavirus-2 (SARS-CoV-2). Health workforce efforts to break the chain of virus transmission in Health Service Facilities.Therefore it is very important to apply knowledge and perceptions of transmission of COVID-19. Some literature states thatthere is a relationship between one's compliance with knowledge and perception. However, other researchers said there wasno linkage of deficiencies, so researchers wanted to see which one was most appropriate about this. To determine therelationship between nurses' compliance implementing COVID-19 Pandemic Health Protocol with COVID-19 knowledgedand perception of COVID-19.. Caterogical analysis using cross sectional design. Nurses working at Avicenna Bireuen Hospitalin 2020. The research data were obtained from primary data using a COVID-19 Health Protocol compliance questionnaire,knowledge and perception questionnaire of COVID-19. Then do to analysis with the Chi Square test. The results of ChiSquare test showed that there was a significant relationship between nurses' compliance implementing COVID-19 pandemichealth protocol with knowledge of COVID- 19 wih a value of P=0.004 (p<0.05) and perceptions of COVID-19 with a value ofP=0.012 (p<0.05). Nurses who adhere to the COVID-19 pandemic health protocol have good knowledge of COVID-19 andgood perceptions of COVID-19.
EVALUASI HASIL INVESTIGASI KONTAK SERUMAH PADA PASIEN TUBERKULOSIS DI KOTA MEDAN MAULIDA SHAFI; ISTI ILMIATI FUJIATI; ELMAN BOY; DES SURYANI
JURNAL ILMIAH SIMANTEK Vol 5 No 2 (2021): JURNAL ILMIAH SIMANTEK
Publisher : LP2MTBM MAKARIOZ

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Abstract

This study aims to determine the distribution of TB suspects based on demographics, symptoms, and risk factors and therelationship between household contact with TB suspects. This study used a descriptive method with cross sectional design.Data were processed using SPSS Chi-Square test. The results showed that the frequency of TB suspects in people whocontact with TB patients by age was at the age of 21-40 years, based on gender the most frequency was found in males 41people (62.1%). Based on symptoms obtained frequency the most common symptom was cough (89.4%), based on the riskfactor for the most frequency in smokers (19.7%), and based on the relationship of household contact with suspected TBusing the Chi-square statistical test showed that the probability value (p) <0.05 (p = .000). This means that at the 95%significance level with ɑ = 0.05, there is a significant relationship between household contact with TB patients with suspectedTB. From the results of the study it was found that the frequency of TB suspicion among people who had household contactwith TB patients based on age at most was in the age group of 21-40 years totaling 19 patients (28.8%).
Co-Authors AQILAH HANIFA Balemun Kaisar Harahap Cindy Mentari Debby Mirani Lubis DEDY DWI PUTRA Ecie Budiyanti Eka Airlangga ELMAN BOY Fadhila, Mutia Fadhilla Qudsi Ramadhani Fadhilla Qudsi Ramadhani Febriyanti, Eka Fujiati, Isti Ilmiati HANNY RAHMI LUBIS Hidayati, Nurul Hildaini Fatma Tanjung Humairah Medina Liza Lubis Ika Nopa IKHFANA SYAFINA Jeanne Adiwinata Pawitan KARTIKA HANDAYANI MAULIDA SHAFI Muhammad Edy Syahputra Nasution Muhammad Iqbal Mutia Fadhilla Nathasya Putri Kinanti Nuralita, Nanda Sari Nurfadhilah Amini Nasution Nurhakiki Zahara Arif Nurhasanah Nurhasanah Octari Auliati Pertiwi, Retno Ratih Yulistika Utami Ritonga, Annisa Qarunia RIZKY NURDIANTY Septi Dwi Pratiwi Shinta Damayanti Siregar, Pinta Pudiyanti Siti Mirhalina Hasibuan Vici Vitricia Melja WIDYA AFIFAH Zakiya Rafwiani