<![CDATA[Malaria remains a major global health problem. Immunoglobulin G (IgG) plays a key role in naturally acquired immunity and is associated with disease progression. Goat bile (GB) has traditionally been used as an antimalarial remedy; however, its effects on immunity and the balance between its efficacy and toxicity remain unclear. This study evaluated the effect of GB on anti-Plasmodium berghei IgG levels and their association with parasitemia and survival in infected mice. Fifty male mice were divided into five groups (n = 10 per group) and infected with P. berghei. Three groups received GB at 25% (GB25), 50% (GB50), and 100% (GB100). The positive control group (POS) received dihydroartemisinin–piperaquine (DHP: 187.2 mg/kg body weight), and the negative control group (NEG) received sterile water. Parasitemia was monitored daily, and IgG levels were measured by indirect ELISA (OD450) after 4 days of treatment. GB100 produced the lowest parasitemia (16.76% ± 1.41) but reduced survival (60%). GB25 and GB50 showed moderate parasitemia (35.80% ± 4.03 and 31.21% ± 4.31, respectively) with 100% survival. IgG levels were highest in the untreated mice (NEG) group (3.70 ± 0.21) and significantly lower in all treated groups (p < 0.01). GB demonstrated anti-plasmodial activity, with greater parasite suppression at higher concentrations. However, GB100 was associated with reduced survival and diarrhea, indicating treatment-related toxicity. Lower parasite burden was accompanied by lower anti-P. berghei-specific IgG levels. These findings suggest that parasite suppression, survival, and parasite-specific IgG responses should be considered together when evaluating the therapeutic potential of goat bile.]]>
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