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The differences of parasitemia and lungs size in malaria-associated acute respiratory distress syndrome (MA-ARDS) and non-MA-ARDS in mice infected with Plasmodium berghei ANKA Eka Noviya Fuzianingsih; Cyuzuzo Callixte; Marselaonety La’lang; Dinda Eka Putri; Heny Arwati; Lucia Tri Suwanti
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 6, No 1 (2022): Journal Qanun Medika Vol 6 No 01
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v6i1.8853

Abstract

Malaria-associated acute respiratory distress syndrome (MA-ARDS) is characterized by extensive infiltration of leukocytes, microhemorrhages, vasogenic edema, changes in lung color, and a significant increase in the weight of the lung. This study was aimed to find out the differences in parasitemia and lung size in MA-ARDSand non-MA-ARDSin mice infected with Plasmodium berghei ANKA. Sixteen male BALB/c mice were infected with P. berghei ANKA, and daily parasitemia was observed on Giemsa-stained tail blood smears. Mice were sacrificed when parasitemia reached ±20%. Simultaneously eight uninfected mice were used as negative control (NEG). The statistical analysis was done using Kruskal Wallis, Mann Whitney U tests, and Spearman correlation test. The results showed that there were significant differences in parasitemia (p=0.001), weight (p=0.001), and lung length (p=0.021) between the MA-ARDS and non-MA-ARDS groups. Comparison of NEG and MA-ARDS resulted in a significant difference in lung size (p=0.05). When non-MA-ARDScompared with NEG groups, it showed a significant difference in lung width (p=0.001). However, there was no significant difference in lung weight and length (p>0.05). Spearman correlation test showed that there was a strong correlation between parasitemia with weight (p=0.000), length (p=0.001), and lung width (p=0.017). The findings indicated that parasitemia played a role in the development of MA-ARDS in mice infected with P. berghei ANKA and influenced the size of the lung. 
Age and Knee Osteoarthritis Severity Relationship in Indonesian Secondary Referral Hospital Panji Sananta; Haidar Abror Firladi; Dhelya Widasmara; Eka Noviya Fuzianingsih
Jurnal Berkala Kesehatan Vol 8, No 2 (2022): JURNAL BERKALA KESEHATAN
Publisher : Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v8i2.14608

Abstract

Osteoarthritis is a chronic joint disease that causes pain, disability, and loss of function. More than 80% of cases of osteoarthritis affect the knee joint. The exact cause of knee osteoarthritis is still unknown, but it is generally associated with aging and obesity. This study aimed to determine the relationship between age and the severity of knee osteoarthritis. This research used a cross-sectional study involving patients who suffered from knee osteoarthritis. Data on gender and the severity of osteoarthritis was collected from medical records. The severity of knee osteoarthritis was assessed using the Kellgren-Lawrence system. The data was analyzed using the Spearman correlation. There were 3 patients (8.1%) in the category of late adulthood, 7 patients (18.9%) in the middle-aged category, 13 patients (35.1%) in the early-onset elderly category, and 14 patients (37.8%) in the elderly. Seven patients (23.7%) suffered from osteoarthritis grade 1, 13 patients (35.1%) had grade 2, 16 patients (43.2%) had grade 3, and one patient had grade 4. The Spearman test showed that there was no significant relationship (p>0.05) between age and the severity of knee osteoarthritis. According to the study's findings, there was no correlation between age and the severity of knee osteoarthritis in women and men patients at Baptis Hospital, Batu City.
Association between the degree of Osteoarthritis and pain level of patients at Baptist Hospital, Batu City Panji Sananta; Hansel Hansel; Dhelya Widasmara; Eka Noviya Fuzianingsih
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 7 No 1 (2023): Qanun Medika Vol 07 No 01 January 2023
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v7i1.13483

Abstract

Osteoarthritis is a chronic disease characterized by the destruction of cartilage in the joints, causing stiffness, pain, and impaired movement. The condition most commonly affects the joints of the knees, hands, feet, spine, and often the shoulders and hips. Knee osteoarthritis is a major public health problem that causes chronic pain and reduces physical function and quality of life. This study determined the relationship between the degree of Osteoarthritis and the pain level in patients at Baptist Hospital, Batu City. This research used a cross-sectional study with 31 respondents. Data collection was conducted directly using the WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) questionnaire, modified in Indonesian. To determine the grade of Osteoarthritis using the Kellgren-Lawrence system. The results showed that out of 31 respondents, there were nine patients (29%) who had grade 1 osteoarthritis, 12 patients (38.7%) had grade 2, and 10 patients (32.3%) had grade 3. There were 22 patients (71%) who had a mild pain level, four patients (13%) had a moderate level, and five patients (16%) had a severe pain level. The Spearman correlation test showed no significant relationship (p>0.05) between the degree of Osteoarthritis and the level of pain in patients. This study concludes that there was no relationship between the increasing degree of Osteoarthritis and the level of pain.
Body Mass Index and Knee Osteoarthritis: A Retrospective Cross-Sectional Study in Baptis Hospital, Batu City Panji - Sananta; Wildan Faza Pratama; Dhelya - Widasmara; Eka Noviya Fuzianingsih
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 12, No 1 (2023): March 2023
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v12i1.2595

Abstract

Osteoarthritis is a chronic global and musculoskeletal disorder. This disease is associated with reduced articular cartilage integrity. The most commonly affected joint is the knee, followed by the hand and the hip. Knee osteoarthritis is associated with aging, obesity, articular cartilage, fatigue, trauma, and congenital joint deformities. Excess body weight is a factor that will exacerbate osteoarthritis. There are still meta-analysis studies involving cohort and case-control studies on osteoarthritis and body mass index (BMI) available, but the relationship between the two variables is still not assessed quantitatively. In addition, research on knee osteoarthritis and BMI is still limited, particularly at Baptis Hospital, where it has never been done. As a result, this study was carried out to determine the relationship between BMI and the degree of knee osteoarthritis. This retrospective cross-sectional study involved 33 patients who suffered from knee osteoarthritis. Data were collected from medical records, and the Kellgren-Lawrence system to assess the degree of knee osteoarthritis based on radiology findings. A total of 7 patients (21.2%) suffered from osteoarthritis grade 1, 10 patients (30.3%) had degree 2, 15 patients (45.5%) had degree 3, and one patient had degree 4. The Spearman correlation test showed that there was no significant relationship (p>0.05). So, it can be concluded from this study that there was no correlation between BMI and the degree of knee osteoarthritis patients at Baptis Hospital, Batu City.
Treatment in transient synovitis cases: A review Panji - Sananta; Fernaldhi - Anggadha; Eka Noviya Fuzianingsih
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 8 No 01 (2024): Qanun Medika Vol 08 No 01 January 2024
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v8i01.17967

Abstract

Inflammation of the synovial membrane of a joint is a common symptom of transient synovitis (TS), which is the medical term for a condition that leads to hip discomfort in juvenile patients.  The estimated annual incidence of TS is 0.2%, and the risk of developing the disease over one's lifetime is 3%.  Unfortunately, the specific pathophysiology of TS is still unclear.  Therefore, the particular treatment is still debatable.  There are several methods of treating TS, starting with bed rest in the hospital and using analgesics, steroids, skin traction, and joint aspiration.  Most of the time, transient synovitis is a self-limiting condition that heals independently and is managed conservatively by monitoring and rest.  Several medical therapy options, including analgesics, NSAIDs, and corticosteroids, speed up healing.  On the other hand, skin traction is also reported to provide beneficial therapeutic effects for TS patients.  Thus, with many therapeutic options, TS's "golden" management still needs further study.
A literature review of current surgical treatment for congenital pseudoarthrosis of the tibia Panji - Sananta; Ade Yahya Nasution; Eka Noviya Fuzianingsih
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 8 No 02 (2024): Qanun Medika Vol 08 No 02 2024
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v8i02.19066

Abstract

Congenital pseudarthrosis of the tibia (CPT) is an infrequently observed condition. However, it is considered to be one of the most complex ailments in the field of pediatric orthopedics. In cases where a tibial fracture is absent, the conventional treatment approach involves using bracing as a preventive measure against fractures. Various surgical modalities have been proposed for the management of CPT, including intramedullary (IM) rod fixation, external fixators, on-lay grafts, cancellous grafts, periosteal grafts, Paley cross-union, amputation, vascularized fibula grafts, and induced membrane techniques. These modalities can be used in different combinations and permutations. The need for repetitive surgical interventions due to unsuccessful therapeutic outcomes or modifications in secondary treatments can significantly disrupt the childhood experience, resulting in prolonged and recurrent functional limitations. In certain instances, amputation may be required as a primary or secondary treatment modality. This literature review will clarify the current surgical interventions for CPT disease based on a summary of research data. The surgery the patient receives significantly impacts their general health and capacity to heal.
A literature review of diagnosing transient synovitis hip disease: English Panji - Sananta; Agung Ismanuworo; Eka Noviya Fuzianingsih
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 8 No 02 (2024): Qanun Medika Vol 08 No 02 2024
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v8i02.20329

Abstract

Transient synovitis (TS), an abrupt, non-specific synovium inflammation, is the most prevalent cause of pediatric hip discomfort. Transient synovitis affects 3–10-year-olds. This disease is benign and self-limiting, but clinicians must distinguish it from an acute infection. After ruling out other causes of hip discomfort and limping, clinicians detect transient synovitis. Based on the patient's history, physical examination, and hip radiography, septic arthritis (SA) and TS care are the most likely causes. Clinicians must consider clinical factors and order appropriate lab and imaging tests to rule out alternative illnesses. This review aims to determine how to propose TS hip disease. The databases used were Scopus and PubMed. We included seven articles in our review. Clinical symptoms, lab testing, and radiographs determine the diagnosis. Ultrasound is a useful TS diagnostic tool since it is widely available, and children are not directly exposed to ionizing radiation. If TS and SA illnesses, which are commonly linked, are unclear, detecting bone marrow abnormalities, soft tissue lesions, synovial enhancement, and joint effusion by MRI can be beneficial. Laboratory tests help distinguish TS from SA because there are more extensive evaluations. Additionally, the healthcare provider performs a hip joint aspiration examination under ultrasound or fluoroscopy.
Management of Habitual Patellar Dislocation in Pediatrics Panji - Sananta; Ade Churie Tanjaya; Eka Noviya Fuzianingsih
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 9 No 01 (2025): Qanun Medika Vol 09 No 01 January 2025
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v9i01.22714

Abstract

Habitual patellar dislocation occurs when the knee is bent and returns to its usual position when straightened. Habitual patella dislocation is 13.5 per 100,000 in children under 13 and 147.7 per 100,000 in children 14–18. This review aims to present a comprehensive and complete literature on the management of habitual dislocation of the patella so that appropriate therapy can be obtained. A complete literature review was used in this investigation. Source search databases are PubMed, Science Direct, and Google Scholar. The literature study shows that habitual patellar dislocation in children is infrequent. Stability requires bone and connective tissue that match the patellofemoral joint. Patella alta, torsional, angular, trochlear dysplasia, muscular anomalies, ligamentous laxity, or ligament damage can produce lateral patellar habitual instability. The quadriceps muscle drags laterally to the limb's mechanical axis. Clinical children with recurrent patellar dislocation may experience a sudden dislocation that "disappeared somewhere." If this condition returns, patients frequently develop unusual knee edema and inflammation. MRI, CT, and plain radiography can diagnose this condition. A CT scan can detect trochlear dysplasia. Joint effusion, osteochondral lesions, medial retinaculum tears, and medial patella and lateral femoral condyle cartilaginous discolorations can be seen by MRI. Conservative or surgical treatment of habitual patellar dislocation depends on the deformity and its effects.
The role of bisphosphonate and bone morphogenetic proteins in congenital pseudoarthrosis of the tibia management: a literature review Panji Sananta; Adithya Stephana Mahendra; Eka Noviya Fuzianingsih
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 2 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i2.20291

Abstract

Congenital pseudoarthrosis of the tibia (CPT) is a rare medical condition characterized by a congenital absence of union in the tibia, which causes the leg to flex anterolaterally. Despite the use of several surgical techniques for the treatment of CPT, there is still a significant risk of failure with surgical interventions. Recent studies have shown that bisphosphonates (BP) and bone morphogenetic proteins (BMP) can be effective adjuncts to surgical procedures, increasing the success rate of bone union and reducing the chance of re-fracture. This review aimed to evaluate the role of BP and BMP in CPT. In this review, a comprehensive literature evaluation was conducted using the PRISMA method. The databases used to search for information included PubMed, ScienceDirect, and Google Scholar for the past 10 years. Six articles were included in this review. The results showed that using pharmacological agents such as BMP and BP is considered safe for pediatric patients as an adjunctive treatment to surgery. This combination can effectively increase the speed of bone union and prevent re-fractures. The small sample size, different protocols, and different doses may have impacted the study results, which should be thoroughly explained.
THE POTENCIES OF AUTOLOGOUS-CONDITIONED PLASMA FOR THE TREATMENT OF OSGOOD–SCHLATTER DISEASE: A LITERATURE REVIEW SANANTA, PANJI; PUTRA, YUDHA ANANTHA KHAERUL; FUZIANINGSIH, EKA NOVIYA
Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Vol 8, No 1 (2025): Al-Iqra Medical Journal: Jurnal Berkala Ilmiah Kedokteran
Publisher : Journal Medical Universitas muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/aimj.v8i1.15814

Abstract

Osgood-Schlatter disease (OSD) is characterized by inflammation of the patellar ligament at the tibial tuberosity resulting from growth-related overuse. Traction apophysitis of the anterior component of the tibial tuberosity (ATT) happens when the quadriceps muscle contracts at the point where the proximal tibial apophysis attaches to the tibia. The recommended interventions include the administration of analgesics, the provision of instruction on physical activity, and the implementation of physiotherapy. However, the duration of signs and symptoms can be extended. Autologous-conditioned plasma (ACP) injections are increasingly being employed in treating various musculoskeletal diseases due to their elevated concentration levels of growth factors compared to whole blood. The Autologous Concentrated Platelets (ACP) solution consists solely of platelet-rich plasma (PRP) devoid of leukocytes. This concentrated PRP will be administered via injection into the affected trauma region. The present literature evaluation used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology. The current literature review demonstrates that autologous conditioned plasma (ACP) is a suitable alternative therapy for osteochondritis dissecans (OSD). The efficacy of OSD treatment can be enhanced by administering autologous conditioned plasma (ACP) into the affected region. Using autologous conditioned plasma (ACP) to treat orthopaedic and traumatological conditions, such as OSD and other musculoskeletal injuries, has much potential as a therapeutic intervention in orthopaedics and traumatology.