Perineal wounds are a common occurrence following vaginal delivery and require an optimal healing process during the postpartum period. Perineal wound healing is influenced by various factors. This study aims to identify and synthesize the factors associated with perineal wound healing in postpartum women. A literature review was conducted by searching for articles on PubMed, with Google Scholar serving as an additional source. Articles published between 2021 and 2025 in either Indonesian or English were selected based on inclusion and exclusion criteria. A total of 11 observational studies met the criteria and were included in the review from 735 study. The synthesis indicates that perineal wound healing is associated with various factors, including maternal characteristics (age and parity); biological and nutritional factors (nutritional status, diet, Body Mass Index [BMI], and hemoglobin levels); behavioral factors (knowledge, personal hygiene, wound care, and mobilization); as well as wound characteristics, therapeutic interventions, and sociocultural factors. Perineal wound healing in postpartum women is a multidimensional process linked to maternal, biological, nutritional, and behavioral factors, as well as wound characteristics and sociocultural influences.
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