Understanding Gastrointestinal Involvement in Juvenile Idiopathic Arthritis: A Perspective from Within the Gut

Saskia Ratna Desita (Faculty of Medicine, Airlangga University)
Nadira Muthi Tsania (Faculty of Medicine, Airlangga University)

Formosa Journal of Science and Technology (FJST)
Vol. 4 No. 2 (2025): February 2025

Juvenile idiopathic arthritis (JIA) is the most common form of arthritis affecting the pediatric population. Gastrointestinal diseases such as Inflammatory Bowel Disease (IBD) and Celiac Disease (CD) are more prevalent in patients with JIA. Alteration in gut microbiota composition results in immune dysregulation, disruption of the gut mucosal barrier, and altered intestinal functionality. Furthermore, medication commonly prescribed for JIA patients impacts intestinal health. Management strategies have been suggested to address these complications, including proton pump inhibitors (PPIs), folic acid supplementation, and proper nutrition. This literature review aims to explore the mechanisms underlying gastrointestinal involvement in JIA, assess the impact of commonly used medications, and provide insights into the clinical implications and management.