Acta Interna : The Journal of Internal Medicine
Vol 4, No 2 (2014): The Journal of Internal Medicine

Telomere and telomerase in hematological disorders Focusing on bone marrow failure syndromes and hematological malignancies

Mardiah Suci Hardianti (Unknown)
Ibnu Purwanto (Unknown)
Johan Kurnianda (Unknown)

Article Info

Publish Date
01 Dec 2016

Abstract

ABSTRACTWe review the present knowledge of telomeres and telomerase with special attention to their role in hematological disorders especially bone marrow failure syndromes including acquired aplastic anemia and myelodysplastic syndromes, as well as acute and chronic myeloid leukemia. The current understanding on the role of telomere and telomeres dysfunctions in hematological disorders leads us to a better understanding on the pathology of the diseases as well as considering some possibilities to employ the measurement of telomere length and telomere activity in disease prognostication. Several treatment options targeting telomere and telomerase being developed are also reviewed.Keywords: telomere- telomerase- bone marrow failure syndromes- hematological malignancies

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Journal Info
Acta Interna : The Journal of Internal Medicine
Website

Abbrev

jain

Publisher

Universitas Gadjah Mada

Subject

Health Professions Medicine & Pharmacology

Description

The Journal considers any original research that advocates change in, or illuminates, clinical practice. The journal also publishes interesting and informative reviews and opinions pieces on any topics connected with clinical practice. Manuscripts must be solely the work of the author(s) stated, not ...