<![CDATA[Tuberculosis (TB) requires regular treatment over an extended period. Adverse drug reactions (ADRs) to anti-tuberculosis drugs (ATDs) may pose challenges during therapy; therefore, patient monitoring and counseling are essential. This study aimed to analyze the association between the severity of ATD adverse effects and medication adherence among patients with pulmonary TB at Tumbang Sangai Primary Health Center. An analytical observational study with a cross-sectional design was conducted. A total of 32 patients were recruited using accidental sampling. Questionnaires assessing TB drug adverse effects and medication adherence were utilized as research instruments. The results showed that 26 patients (81.3%) experienced severe adverse effects, 3 (9.4%) experienced moderate adverse effects, and 3 (9.4%) experienced mild adverse effects. Regarding medication adherence, 24 patients (75.0%) were classified as adherent, while 8 (25.0%) were classified as non-adherent. Notably, 81.3% of patients experienced severe adverse effects, although the overall medication adherence rate was 75.0%. Statistical analysis using the Fisher-Freeman-Halton exact test revealed a significant association between ATD adverse effects and medication adherence (p = 0.035; p < 0.05). In conclusion, a significant association was found between ATD adverse effects and medication adherence among patients with pulmonary TB at Tumbang Sangai Primary Health Center.]]>
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